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Mouse Anti-EIF2S2 (AA 1-100) Recombinant Antibody (CBFYE-0667) (CBMAB-E1084-FY)

This product is mouse antibody that recognizes EIF2S2. The antibody CBFYE-0667 can be used for immunoassay techniques such as: ELISA, IF, IHC-P, WB.
See all EIF2S2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-0667
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-101 from human EIF2S2 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
Eukaryotic Translation Initiation Factor 2 Subunit Beta
Introduction
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human8894
Mouse67204
Rat296302
UniProt ID
HumanP20042
MouseQ99L45
RatQ6P685
Alternative Names
Eukaryotic Translation Initiation Factor 2 Subunit Beta; Eukaryotic Translation Initiation Factor 2, Subunit 2 Beta, 38kDa; Protein Phosphatase 1, Regulatory Subunit 67; EIF-2-Beta; EIF2B; Eukaryotic Translation Initiation Factor 2, Subunit 2 (Beta, 38kD )
Research Area
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Biological Process
Formation of cytoplasmic translation initiation complex Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
In utero embryonic development Source: Ensembl
Male germ cell proliferation Source: Ensembl
Male gonad development Source: Ensembl
Cellular Location
Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2 complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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