FIS1

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM

Full Name

fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

Function

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Biological Process

Autophagy of mitochondrion Source: UniProtKB
Calcium-mediated signaling using intracellular calcium source Source: UniProtKB
Cellular response to glucose stimulus Source: Ensembl
Cellular response to peptide Source: Ensembl
Cellular response to thapsigargin Source: Ensembl
Cellular response to toxic substance Source: Ensembl
Mitochondrial fission Source: UniProtKB
Mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Negative regulation of ATP metabolic process Source: ARUK-UCL
Negative regulation of endoplasmic reticulum calcium ion concentration Source: UniProtKB
Negative regulation of fatty acid transport Source: ARUK-UCL
Peroxisome fission Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of protein targeting to membrane Source: UniProtKB
Protein targeting to mitochondrion Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB
Response to flavonoid Source: Ensembl
Response to fluoride Source: Ensembl
Response to hypobaric hypoxia Source: Ensembl
Response to muscle activity Source: Ensembl
Response to nutrient levels Source: Ensembl

Cellular Location

Peroxisome membrane; Mitochondrion outer membrane

Topology

Cytoplasmic: 1-122
Helical: 123-143
Lumenal: 144-152

PTM

Ubiquitinated by MARCHF5.