FIS1
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM
Full Name
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
Biological Process
Autophagy of mitochondrion Source: UniProtKB
Calcium-mediated signaling using intracellular calcium source Source: UniProtKB
Cellular response to glucose stimulus Source: Ensembl
Cellular response to peptide Source: Ensembl
Cellular response to thapsigargin Source: Ensembl
Cellular response to toxic substance Source: Ensembl
Mitochondrial fission Source: UniProtKB
Mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Negative regulation of ATP metabolic process Source: ARUK-UCL
Negative regulation of endoplasmic reticulum calcium ion concentration Source: UniProtKB
Negative regulation of fatty acid transport Source: ARUK-UCL
Peroxisome fission Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of protein targeting to membrane Source: UniProtKB
Protein targeting to mitochondrion Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB
Response to flavonoid Source: Ensembl
Response to fluoride Source: Ensembl
Response to hypobaric hypoxia Source: Ensembl
Response to muscle activity Source: Ensembl
Response to nutrient levels Source: Ensembl
Calcium-mediated signaling using intracellular calcium source Source: UniProtKB
Cellular response to glucose stimulus Source: Ensembl
Cellular response to peptide Source: Ensembl
Cellular response to thapsigargin Source: Ensembl
Cellular response to toxic substance Source: Ensembl
Mitochondrial fission Source: UniProtKB
Mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Negative regulation of ATP metabolic process Source: ARUK-UCL
Negative regulation of endoplasmic reticulum calcium ion concentration Source: UniProtKB
Negative regulation of fatty acid transport Source: ARUK-UCL
Peroxisome fission Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of protein targeting to membrane Source: UniProtKB
Protein targeting to mitochondrion Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB
Response to flavonoid Source: Ensembl
Response to fluoride Source: Ensembl
Response to hypobaric hypoxia Source: Ensembl
Response to muscle activity Source: Ensembl
Response to nutrient levels Source: Ensembl
Cellular Location
Peroxisome membrane; Mitochondrion outer membrane
Topology
Cytoplasmic: 1-122
Helical: 123-143
Lumenal: 144-152
Helical: 123-143
Lumenal: 144-152
PTM
Ubiquitinated by MARCHF5.
View more
Anti-FIS1 antibodies
+ Filters
Loading...
CompareTarget: FIS1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 1G9
Application*: WB, IP, IF, E, P
Target: FIS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2174
Application*: WB, IP, IF, E
Target: FIS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-0685
Application*: IF, WB, P
Target: FIS1
Sensitivity: 0.055 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: FIS1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C8
Application*: WB, E
Target: FIS1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1282
Application*: IF, WB
Target: FIS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-1281
Application*: E, WB
Target: FIS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3034
Application*: IF, WB
Target: FIS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2173
Application*: WB, IP, IF, E
Target: FIS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 27B4
Application*: E, WB, IH
More Infomation
Hot products 
-
Mouse Anti-ELAVL4 Recombinant Antibody (6B9) (CBMAB-1132-YC)
-
Mouse Anti-GP1BA Recombinant Antibody (6D1) (CBMAB-0271-CN)
-
Mouse Anti-BLK Recombinant Antibody (CBYY-0618) (CBMAB-0621-YY)
-
Mouse Anti-GZMA Recombinant Antibody (CBLG1-2197) (CBMAB-G5901-LY)
-
Mouse Anti-dsRNA Recombinant Antibody (2) (CBMAB-D1807-YC)
-
Mouse Anti-CCNH Recombinant Antibody (CBFYC-1054) (CBMAB-C1111-FY)
-
Mouse Anti-COL1A2 Recombinant Antibody (CF108) (V2LY-1206-LY626)
-
Mouse Anti-AKT1/AKT2/AKT3 (Phosphorylated T308, T309, T305) Recombinant Antibody (V2-443454) (PTM-CBMAB-0030YC)
-
Mouse Anti-EGR1 Recombinant Antibody (CBWJZ-100) (CBMAB-Z0289-WJ)
-
Mouse Anti-DLL4 Recombinant Antibody (D1090) (CBMAB-D1090-YC)
-
Mouse Anti-HTLV-1 gp46 Recombinant Antibody (CBMW-H1006) (CBMAB-V208-1154-FY)
-
Mouse Anti-CFL1 Recombinant Antibody (CBFYC-1771) (CBMAB-C1833-FY)
-
Mouse Anti-CD24 Recombinant Antibody (ALB9) (CBMAB-0176CQ)
-
Mouse Anti-8-oxoguanine Recombinant Antibody (V2-7697) (CBMAB-1869CQ)
-
Mouse Anti-2C TCR Recombinant Antibody (V2-1556) (CBMAB-0951-LY)
-
Mouse Anti-BCL2L1 Recombinant Antibody (H5) (CBMAB-1025CQ)
-
Mouse Anti-G6PD Recombinant Antibody (13B331) (CBMAB-G1553-LY)
-
Mouse Anti-C5AR1 Recombinant Antibody (R63) (CBMAB-C9553-LY)
-
Mouse Anti-CD59 Recombinant Antibody (CBXC-2097) (CBMAB-C4421-CQ)
-
Mouse Anti-GDF5 Recombinant Antibody (1F4) (CBMAB-G2740-LY)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry