FSTL1

This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.
Full Name
Follistatin Like 1
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692).

Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity).

Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity).

Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).
Biological Process
Cell differentiation Source: GO_Central
Endothelial cell differentiation Source: UniProtKB
Endothelial cell migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Cellular Location
Secreted
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Anti-FSTL1 antibodies

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Target: FSTL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-1691
Application*: WB
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1895
Application*: IF
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2680
Application*: WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2679
Application*: WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: CBXF-2678
Application*: IC
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0938
Application*: E, P, WB
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0937
Application*: E, P, WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXF-2184
Application*: WB
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2477
Application*: F, IF
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-2420
Application*: WB
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1894
Application*: F, IF
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-1895
Application*: E
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2680
Application*: E
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2679
Application*: WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2678
Application*: WB
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXF-0938
Application*: E
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0937
Application*: E
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-2420
Application*: WB, E
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1894
Application*: IF
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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