FSTL1
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.
Full Name
Follistatin Like 1
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692).
Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity).
Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity).
Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).
Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity).
Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity).
Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).
Biological Process
Cell differentiation Source: GO_Central
Endothelial cell differentiation Source: UniProtKB
Endothelial cell migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Endothelial cell differentiation Source: UniProtKB
Endothelial cell migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Cellular Location
Secreted
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Anti-FSTL1 antibodies
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CompareTarget: FSTL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-1691
Application*: WB
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1895
Application*: IF
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2680
Application*: WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2679
Application*: WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: CBXF-2678
Application*: IC
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0938
Application*: E, P, WB
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0937
Application*: E, P, WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXF-2184
Application*: WB
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2477
Application*: F, IF
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-2420
Application*: WB
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1894
Application*: F, IF
Target: Fstl1
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: FSTL1
Sensitivity: 3.32 ng/mL
Detection Range: 7-1500 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Fstl1
Sensitivity: 3.18 ng/mL
Detection Range: 6-1800 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: FSTL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-306
Tag: His Tag
Target: FSTL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-308
Tag: His Tag
Target: FSTL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-306
Tag: His Tag
Target: FSTL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-306
Tag: hFc Tag
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-1895
Application*: E
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2680
Application*: E
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2679
Application*: WB
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2678
Application*: WB
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXF-0938
Application*: E
Target: FSTL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0937
Application*: E
Target: FSTL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-2420
Application*: WB, E
Target: FSTL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1894
Application*: IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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