Rat Anti-FSTL1 Recombinant Antibody (CBXF-2678) (V2LY-1225-LY174)

Name: Rat Anti-FSTL1 Recombinant Antibody (CBXF-2678)
SKU: V2LY-1225-LY174
Rating: 5 (1 reviews)

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Published Data

Rat Anti-FSTL1 Recombinant Antibody (CBXF-2678) (V2LY-1225-LY174) in ELISA

FSTL1 protein in serum of C57BL/6J mice at the different time-point after silica injury was determined by ELISA analysis (n=6 per group; *P<0.05; **P<0.01 by one-way ANOVA followed by Student's t test). ...View More

Fang, Y., Zhang, S., Li, X., Jiang, F., Ye, Q., & Ning, W. (2017). Follistatin like-1 aggravates silica-induced mouse lung injury. Scientific Reports, 7(1), 399.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXF-2678

Application

Immunogen

Recombinant human Follistatin-like 1/FSTL1 (Met1-Ile308).

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Follistatin Like 1

Entrez Gene ID

11167

UniProt ID

Q12841

Function

Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692).

Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity).

Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity).

Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).

Biological Process

Cell differentiation Source: GO_Central
Endothelial cell differentiation Source: UniProtKB
Endothelial cell migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central

Cellular Location

Secreted

Ogiwara, Y., Nakagawa, M., Nakatani, F., Uemura, Y., Zhang, R., & Kudo-Saito, C. (2022). Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma. Cancer Letters, 537, 215690.

Rao, J., Wang, H., Ni, M., Wang, Z., Wang, Z., Wei, S., ... & Lu, L. (2022). FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2. Gut, 71(12), 2539-2550.

Li, X., Fang, Y., Jiang, D., Dong, Y., Liu, Y., Zhang, S., ... & Ning, W. (2021). Targeting FSTL1 for multiple fibrotic and systemic autoimmune diseases. Molecular Therapy, 29(1), 347-364.

Loh, J. J., Li, T. W., Zhou, L., Wong, T. L., Liu, X., Ma, V. W., ... & Ma, S. (2021). FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and StemnessFSTL1 from Activated Fibroblasts on HCC. Cancer research, 81(22), 5692-5705.

Li, W., Alahdal, M., Deng, Z., Liu, J., Zhao, Z., Cheng, X., ... & Zhang, J. (2020). Molecular functions of FSTL1 in the osteoarthritis. International immunopharmacology, 83, 106465.

Nie, E., Miao, F., Jin, X., Wu, W., Zhou, X., Zeng, A., ... & You, Y. (2019). Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. Oncogene, 38(15), 2706-2721.

Li, X., Li, L., Chang, Y., Ning, W., & Liu, X. (2019). Structural and functional study of FK domain of Fstl1. Protein Science, 28(10), 1819-1829.

Gu, C., Wang, X., Long, T., Wang, X., Zhong, Y., Ma, Y., ... & Li, Z. (2018). FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway. Cell death & disease, 9(6), 654.

Kudo-Saito, C., Ishida, A., Shouya, Y., Teramoto, K., Igarashi, T., Kon, R., ... & Toyoura, M. (2018). Blocking the FSTL1-DIP2A axis improves anti-tumor immunity. Cell reports, 24(7), 1790-1801.

Ni, X., Cao, X., Wu, Y., & Wu, J. (2018). FSTL1 suppresses tumor cell proliferation, invasion and survival in non-small cell lung cancer. Oncology Reports, 39(1), 13-20.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Anti-FSTL1 Recombinant Antibody (CBXF-2678) (CAT#: CBMAB-F3085-CQ)

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Isotype control

For research use only. Not intended for any clinical use.

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