Rat Anti-FSTL1 Recombinant Antibody (CBXF-2679) (CBMAB-F3086-CQ)

Name: Rat Anti-FSTL1 Recombinant Antibody (CBXF-2679)
SKU: CBMAB-F3086-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXF-2679

Application

Immunogen

NS0-derived recombinant human Follistatin-like 1/FSTL1, Met1-Ile308

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Lyophilized from a 0.2 μm filtered solution in PBS with trehalose

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Follistatin Like 1

Introduction

This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.

Entrez Gene ID

11167

UniProt ID

Q12841

Alternative Names

Follistatin Like 1; Follistatin-Like Protein 1; FRP; Follistatin-Related Protein 1; Follistatin-Like 1; MIR198;

Function

Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692).

Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity).

Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity).

Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).

Biological Process

Cell differentiation Source: GO_Central
Endothelial cell differentiation Source: UniProtKB
Endothelial cell migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central

Cellular Location

Secreted

Ogiwara, Y., Nakagawa, M., Nakatani, F., Uemura, Y., Zhang, R., & Kudo-Saito, C. (2022). Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma. Cancer Letters, 537, 215690.

Rao, J., Wang, H., Ni, M., Wang, Z., Wang, Z., Wei, S., ... & Lu, L. (2022). FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2. Gut, 71(12), 2539-2550.

Li, X., Fang, Y., Jiang, D., Dong, Y., Liu, Y., Zhang, S., ... & Ning, W. (2021). Targeting FSTL1 for multiple fibrotic and systemic autoimmune diseases. Molecular Therapy, 29(1), 347-364.

Loh, J. J., Li, T. W., Zhou, L., Wong, T. L., Liu, X., Ma, V. W., ... & Ma, S. (2021). FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and StemnessFSTL1 from Activated Fibroblasts on HCC. Cancer research, 81(22), 5692-5705.

Li, W., Alahdal, M., Deng, Z., Liu, J., Zhao, Z., Cheng, X., ... & Zhang, J. (2020). Molecular functions of FSTL1 in the osteoarthritis. International immunopharmacology, 83, 106465.

Nie, E., Miao, F., Jin, X., Wu, W., Zhou, X., Zeng, A., ... & You, Y. (2019). Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. Oncogene, 38(15), 2706-2721.

Li, X., Li, L., Chang, Y., Ning, W., & Liu, X. (2019). Structural and functional study of FK domain of Fstl1. Protein Science, 28(10), 1819-1829.

Gu, C., Wang, X., Long, T., Wang, X., Zhong, Y., Ma, Y., ... & Li, Z. (2018). FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway. Cell death & disease, 9(6), 654.

Kudo-Saito, C., Ishida, A., Shouya, Y., Teramoto, K., Igarashi, T., Kon, R., ... & Toyoura, M. (2018). Blocking the FSTL1-DIP2A axis improves anti-tumor immunity. Cell reports, 24(7), 1790-1801.

Ni, X., Cao, X., Wu, Y., & Wu, J. (2018). FSTL1 suppresses tumor cell proliferation, invasion and survival in non-small cell lung cancer. Oncology Reports, 39(1), 13-20.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Anti-FSTL1 Recombinant Antibody (CBXF-2679) (CAT#: V2LY-1225-LY175)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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