GAS2

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

Full Name

growth arrest-specific 2

Function

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).

Biological Process

Actin crosslink formation Source: GO_Central
Antral ovarian follicle growth Source: Ensembl
Apoptotic process Source: ProtInc
Basement membrane organization Source: Ensembl
Cell cycle Source: UniProtKB-KW
Initiation of primordial ovarian follicle growth Source: Ensembl
Ovulation Source: Ensembl
Regulation of cell shape Source: UniProtKB-KW
Regulation of Notch signaling pathway Source: Ensembl

Cellular Location

Stress fiber; Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.

PTM

Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.

Anti-GAS2 antibodies

Mouse Anti-GAS2 Recombinant Antibody (4E11) (CBMAB-G2122-LY)

Datasheet

SDS

Target: GAS2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4E11

Application*: IF, WB

Rabbit Anti-GAS2 Recombinant Antibody (CBLG1-2587) (CBMAB-G0208-LY)

Datasheet

SDS

Target: GAS2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Human

Clone: CBLG1-2587

Application*: WB

Mouse Anti-GAS2 Recombinant Antibody (CBLG1-3140) (CBMAB-G2124-LY)

Datasheet

SDS

Target: GAS2

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLG1-3140

Application*: WB

Mouse Anti-GAS2 (AA 1-110) Recombinant Antibody (CBFYH-0243) (CBMAB-H1111-FY)

Datasheet

SDS

Target: GAS2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0243

Application*: E, IF, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)