GAS2

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Full Name
growth arrest-specific 2
Function
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).
Biological Process
Actin crosslink formation Source: GO_Central
Antral ovarian follicle growth Source: Ensembl
Apoptotic process Source: ProtInc
Basement membrane organization Source: Ensembl
Cell cycle Source: UniProtKB-KW
Initiation of primordial ovarian follicle growth Source: Ensembl
Ovulation Source: Ensembl
Regulation of cell shape Source: UniProtKB-KW
Regulation of Notch signaling pathway Source: Ensembl
Cellular Location
Stress fiber; Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
PTM
Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.
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Anti-GAS2 antibodies

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Mouse Anti-GAS2 Recombinant Antibody (CBLG1-3140) (CBMAB-G2124-LY)

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Target: GAS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-3140
Application*: WB
Datasheet SDS

Rabbit Anti-GAS2 Recombinant Antibody (CBLG1-2587) (CBMAB-G0208-LY)

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Target: GAS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBLG1-2587
Application*: WB
Datasheet SDS

Mouse Anti-GAS2 Recombinant Antibody (4E11) (CBMAB-G2122-LY)

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Target: GAS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E11
Application*: IF, WB
Datasheet SDS

Mouse Anti-GAS2 (AA 1-110) Recombinant Antibody (CBFYH-0243) (CBMAB-H1111-FY)

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Target: GAS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0243
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-GAS2 Recombinant Antibody (CBLG1-3140) (V2LY-1225-LY696)

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Target: GAS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-3140
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-GAS2 Recombinant Antibody (CBLG1-2587) (V2LY-1225-LY695)

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Target: GAS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2587
Application*: WB, IH
Datasheet SDS

Mouse Anti-GAS2 Recombinant Antibody (4E11) (V2LY-1225-LY694)

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Target: GAS2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 4E11
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-GAS2 Recombinant Antibody (CBFYH-0243) (V2LY-1225-LY693)

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Target: GAS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0243
Application*: IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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