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Rabbit Anti-GAS2 Recombinant Antibody (CBLG1-2587) (CBMAB-G0208-LY)

This product is antibody recognizes GAS2. The antibody CBLG1-2587 immunoassay techniques such as: WB.
See all GAS2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Human
Clone
CBLG1-2587
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
growth arrest-specific 2
Introduction
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Entrez Gene ID
Human2620
Mouse14453
UniProt ID
HumanO43903
MouseP11862
Function
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).
Biological Process
Actin crosslink formation Source: GO_Central
Antral ovarian follicle growth Source: Ensembl
Apoptotic process Source: ProtInc
Basement membrane organization Source: Ensembl
Cell cycle Source: UniProtKB-KW
Initiation of primordial ovarian follicle growth Source: Ensembl
Ovulation Source: Ensembl
Regulation of cell shape Source: UniProtKB-KW
Regulation of Notch signaling pathway Source: Ensembl
Cellular Location
Stress fiber; Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
PTM
Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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