GCA

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq]
Full Name
grancalcin, EF-hand calcium binding protein
Function
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
Biological Process
Membrane fusion Source: ProtInc
Cellular Location
Cytoplasm; Cytoplasmic granule membrane. Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.
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Anti-GCA antibodies

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Mouse Anti-GCA Recombinant Antibody (CBLG1-751) (CBMAB-G2495-LY)

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Target: GCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-751
Application*: WB
Datasheet SDS

Mouse Anti-GCA Recombinant Antibody (3D12) (CBMAB-G2493-LY)

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Target: GCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D12
Application*: E
Datasheet SDS

Mouse Anti-GCA Recombinant Antibody (CBFYH-0275) (CBMAB-H0574-FY)

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Target: GCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0275
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-GCA Recombinant Antibody (CBLG1-751) (V2LY-1225-LY877)

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Target: GCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-751
Application*: WB, E, IP, IF
Datasheet SDS

Mouse Anti-GCA Recombinant Antibody (3D12) (V2LY-1225-LY876)

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Target: GCA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D12
Application*: WB, E, IP, IF
Datasheet SDS

Mouse Anti-GCA Recombinant Antibody (CBFYH-0275) (V2LY-1225-LY875)

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Target: GCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0275
Application*: WB, E, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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