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GCA

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq]

Full Name

grancalcin, EF-hand calcium binding protein

Function

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

Biological Process

Membrane fusion Source: ProtInc

Cellular Location

Cytoplasm; Cytoplasmic granule membrane. Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.

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Anti-GCA antibodies

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Mouse Anti-GCA Recombinant Antibody (CBLG1-751) (CBMAB-G2495-LY)

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Target: GCA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-751

Application*: WB

Mouse Anti-GCA Recombinant Antibody (3D12) (CBMAB-G2493-LY)

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Target: GCA

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3D12

Application*: E

Mouse Anti-GCA Recombinant Antibody (CBFYH-0275) (CBMAB-H0574-FY)

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Target: GCA

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0275

Application*: E, IF, WB

Mouse Anti-GCA Recombinant Antibody (CBLG1-751) (V2LY-1225-LY877)

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Target: GCA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-751

Application*: WB, E, IP, IF

Mouse Anti-GCA Recombinant Antibody (3D12) (V2LY-1225-LY876)

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Target: GCA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3D12

Application*: WB, E, IP, IF

Mouse Anti-GCA Recombinant Antibody (CBFYH-0275) (V2LY-1225-LY875)

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Target: GCA

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0275

Application*: WB, E, IP, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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