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GIMAP5

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

Full Name

GTPase, IMAP Family Member 5

Function

Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity).

Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851).

Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity).

May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity).

May regulate Ca2+ homeostasis by modulating lysosomal Ca2+ stores, preventing its accumulation in the absence of T cell activation (By similarity).

May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).

Cellular Location

Lysosome membrane; Multivesicular body membrane; Endosome membrane. The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications.

Topology

Cytoplasmic: 1-284
Helical: 285-305
Lumenal: 306-307

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Anti-GIMAP5 antibodies

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Rabbit Anti-GIMAP5 Recombinant Antibody (EG1314) (CBMAB-EN1590-LY)

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Target: GIMAP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1314

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (CBMAB-G3501-LY)

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Target: GIMAP5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-1168

Application*: IP, SE, E, WB

Mouse Anti-GIMAP5 Recombinant Antibody (CBFYH-0359) (CBMAB-H1231-FY)

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Target: GIMAP5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0359

Application*: E, IP, WB

Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (V2LY-1225-LY1318)

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Target: GIMAP5

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-1168

Application*: WB, IP, IF, E

Mouse Anti-GIMAP5 Recombinant Antibody (CBFYH-0359) (V2LY-1225-LY1317)

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Target: GIMAP5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0359

Application*: E, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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