GIMAP5

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

Full Name

GTPase, IMAP Family Member 5

Function

Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity).

Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851).

Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity).

May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity).

May regulate Ca2+ homeostasis by modulating lysosomal Ca2+ stores, preventing its accumulation in the absence of T cell activation (By similarity).

May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).

Cellular Location

Lysosome membrane; Multivesicular body membrane; Endosome membrane. The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications.

Topology

Cytoplasmic: 1-284
Helical: 285-305
Lumenal: 306-307