Rabbit Anti-GIMAP5 Recombinant Antibody (EG1314) (CBMAB-EN1590-LY)

Name: Rabbit Anti-GIMAP5 Recombinant Antibody (EG1314)
SKU: CBMAB-EN1590-LY
Rating: 5 (1 reviews)

See all GIMAP5 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1314

Application

WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GIMAP5.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GTPase, IMAP Family Member 5

Introduction

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

Entrez Gene ID

55340

UniProt ID

Q96F15

Alternative Names

GTPase, IMAP Family Member 5; Immune-Associated Nucleotide-Binding Protein 5; Immunity-Associated Nucleotide 5 Protein; IAN4L1; IAN-5; IMAP3; IAN5; Inhibitor Of Radiation- And OA-Induced Apoptosis, Irod/Ian5; Immunity-Associated Nucleotide 4-Like 1 Protein; Immune Associated Nucleotide 4 Like 1 (Mouse);

Function

Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity).

Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851).

Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity).

May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity).

May regulate Ca2+ homeostasis by modulating lysosomal Ca2+ stores, preventing its accumulation in the absence of T cell activation (By similarity).

May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).

Cellular Location

Lysosome membrane; Multivesicular body membrane; Endosome membrane. The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications.

Topology

Cytoplasmic: 1-284
Helical: 285-305
Lumenal: 306-307

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-GIMAP5 Recombinant Antibody (EG1314)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GIMAP5 Recombinant Antibody (CBFYH-0359) (CAT#: CBMAB-H1231-FY)

Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (CAT#: CBMAB-G3501-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry