Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (V2LY-1225-LY1318)

Name: Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168)
SKU: V2LY-1225-LY1318
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (V2LY-1225-LY1318) in IF

The co-location of Gimap5 and M6PR were examined in PC9-Gimap5 cells and Beas-2b-Gimap5 cells. (magnification, × 1000). ...View More

Dai, P., Tang, Z., Ruan, P., Bajinka, O., Liu, D., & Tan, Y. (2021). Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR. Frontiers in oncology, 11, 699847.

Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (V2LY-1225-LY1318) in IF

Gimap5 altered the intracellular distribution of M6PR (magnification, × 400). ...View More

Dai, P., Tang, Z., Ruan, P., Bajinka, O., Liu, D., & Tan, Y. (2021). Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR. Frontiers in oncology, 11, 699847.

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBLG1-1168

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 5-39 within an N-terminal cytoplasmic domain of human GIMAP5.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GTPase, IMAP Family Member 5

Entrez Gene ID

55340

UniProt ID

Q96F15

Function

Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity).

Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851).

Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity).

May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity).

May regulate Ca2+ homeostasis by modulating lysosomal Ca2+ stores, preventing its accumulation in the absence of T cell activation (By similarity).

May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).

Cellular Location

Lysosome membrane; Multivesicular body membrane; Endosome membrane. The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications.

Topology

Cytoplasmic: 1-284
Helical: 285-305
Lumenal: 306-307

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (CAT#: CBMAB-G3501-LY)

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Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (CAT#: CBMAB-G3501-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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