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Mouse Anti-GIMAP5 Recombinant Antibody (CBLG1-1168) (CBMAB-G3501-LY)

This product is antibody recognizes GIMAP5. The antibody CBLG1-1168 immunoassay techniques such as: IP, S-ELISA, ELISA, WB.
See all GIMAP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1168
Antibody Isotype
IgG2a, κ
Application
IP, S-ELISA, ELISA, WB

Basic Information

Immunogen
GIMAP5 (NP_060854.2, 186 a.a. ~ 284 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GTPase, IMAP Family Member 5
Introduction
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
Entrez Gene ID
55340
UniProt ID
Q96F15
Alternative Names
GTPase; IMAP Family Member 5; Immune-Associated Nucleotide-Binding Protein 5; Immunity-Associated Nucleotide 5 Protein; IAN4L1; IAN-5; IMAP3; IAN5; Inhibitor Of Radiation- And OA-Induced Apoptosis; Irod/Ian5; Immunity-Associated Nucleotide 4-Like 1 Protein; Immune Associated Nucleotide 4 Like 1 (Mouse);
Function
Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity).

Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851).

Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity).

May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity).

May regulate Ca2+ homeostasis by modulating lysosomal Ca2+ stores, preventing its accumulation in the absence of T cell activation (By similarity).

May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).
Cellular Location
Lysosome membrane; Multivesicular body membrane; Endosome membrane. The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications.
Topology
Cytoplasmic: 1-284
Helical: 285-305
Lumenal: 306-307
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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