GLYCTK

This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described.

Full Name

glycerate kinase

Biological Process

Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
Protein phosphorylation Source: UniProtKB

Cellular Location

Isoform 1: Cytoplasm
Isoform 2: Cytoplasm; Mitochondrion

Involvement in disease

D-glyceric aciduria (D-GA):
A rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development.

Anti-GLYCTK antibodies

Mouse Anti-GLYCTK Recombinant Antibody (CBLG1-142) (CBMAB-G0552-LY)

Datasheet

SDS

Target: GLYCTK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-142

Application*: E, WB

Mouse Anti-GLYCTK Recombinant Antibody (1B5) (CBMAB-G3983-LY)

Datasheet

SDS

Target: GLYCTK

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 1B5

Application*: E, WB

Rabbit Anti-GLYCTK Recombinant Antibody (EG1327) (CBMAB-EN1604-LY)

Datasheet

SDS

Target: GLYCTK

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1327

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000

Mouse Anti-GLYCTK Recombinant Antibody (CBLG1-1348) (CBMAB-G3984-LY)

Datasheet

SDS

Target: GLYCTK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBLG1-1348

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)