GSTM2

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Full Name
GSTM2
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Cellular response to caffeine Source: BHF-UCL
Glutathione metabolic process Source: UniProtKB
Hepoxilin biosynthetic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Nitrobenzene metabolic process Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
Relaxation of cardiac muscle Source: BHF-UCL
Xenobiotic catabolic process Source: UniProtKB
Cellular Location
Cytoplasm
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Anti-GSTM2 antibodies

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Mouse Anti-GSTM2 Antibody (7BA7) (CBMAB-1310CQ)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7BA7
Application*: E, P, IH, M, WB
Datasheet SDS

Mouse Anti-GSTM2 (AA 90-190) Recombinant Antibody (CBFYH-3485) (CBMAB-H4033-FY)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYH-3485
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-GSTM2 Recombinant Antibody (CBLG1-2037) (CBMAB-G5517-LY)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2037
Application*: WB
Datasheet SDS

Mouse Anti-GSTM2 Recombinant Antibody (CBLG1-2036) (CBMAB-G5516-LY)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBLG1-2036
Application*: E, WB
Datasheet SDS

Mouse Anti-GSTM2 Recombinant Antibody (CBLG1-2035) (CBMAB-G5515-LY)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBLG1-2035
Application*: E, P, WB
Datasheet SDS

Rabbit Anti-GSTM2 Recombinant Antibody (CBLG1-2033) (CBMAB-G5513-LY)

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Target: GSTM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2033
Application*: E, IP
Datasheet SDS

Rabbit Anti-GSTM2 Recombinant Antibody (CBLG1-2032) (CBMAB-G5512-LY)

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Target: GSTM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2032
Application*: WB
Datasheet SDS

Rabbit Anti-GSTM2 Recombinant Antibody (CBLG1-2031) (CBMAB-G5511-LY)

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Target: GSTM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2031
Application*: P
Datasheet SDS

Mouse Anti-GSTM2 Recombinant Antibody (1E10) (CBMAB-G5509-LY)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 1E10
Application*: WB
Datasheet SDS

Rabbit Anti-GSTM2 Recombinant Antibody (11) (CBMAB-G5508-LY)

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Target: GSTM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11
Application*: E, IP
Datasheet SDS

Mouse Anti-GSTM2 Antibody (7BA8) (CBMAB-1311CQ)

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Target: GSTM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7BA8
Application*: E, P, IH, M, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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