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Mouse Anti-GSTM2 (AA 90-190) Recombinant Antibody (CBFYH-3485) (CBMAB-H4033-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYH-3485
Application
ELISA, WB, IHC
Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 90-190
More Infomation

Target

Full Name
GSTM2
Introduction
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta.
Entrez Gene ID
Human2946
Mouse14863
UniProt ID
HumanP28161
MouseP15626
Alternative Names
GST4; GSTM; GTHMUS; GSTM2-2
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Cellular response to caffeine Source: BHF-UCL
Glutathione metabolic process Source: UniProtKB
Hepoxilin biosynthetic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Nitrobenzene metabolic process Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
Relaxation of cardiac muscle Source: BHF-UCL
Xenobiotic catabolic process Source: UniProtKB
Cellular Location
Cytoplasm

Li, C., Liu, J., He, D., Mao, F., Rao, X., Zhao, Y., ... & Liu, X. (2022). GSTM2 is a key molecular determinant of resistance to SG-ARIs. Oncogene, 41(40), 4498-4511.

Zhang, W., Shi, Y., Niu, S., Li, L., Lin, L., Gao, X., ... & Dai, Y. (2022). Integrated computer analysis and a self-built Chinese cohort study identified GSTM2 as one survival-relevant gene in human colon cancer potentially regulating immune microenvironment. Frontiers in Oncology, 12, 881906.

Peng, L., Zhuang, L., Lin, K., Yao, Y., Zhang, Y., Arumugam, T., ... & Huang, H. (2021). Downregulation of GSTM2 enhances gemcitabine chemosensitivity of pancreatic cancer in vitro and in vivo. Pancreatology, 21(1), 115-123.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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