H1-0

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family.
Full Name
H1.0 linker histone
Alternative Names
H10; H1.0; H1F0; H1FV
Function
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Biological Process
Chromosome condensation
Heterochromatin formation
Negative regulation of DNA recombination
Nucleosome assembly
Positive regulation of transcription regulatory region DNA binding
Cellular Location
Nucleus
Chromosome
Note: The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
PTM
Phosphorylated on Ser-17 in RNA edited version.
ADP-ribosylated on Ser-104 in response to DNA damage.
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Anti-H1-0 antibodies

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Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0565) (CBMAB-H1451-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human
Clone: CBFYH-0565
Application*: WB, P, IC, IF
Datasheet SDS

Rabbit Anti-H1-0 Recombinant Antibody (CBNH-063) (CBMAB-R4388-CN)

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Target: H1-0
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-063
Application*: E
Datasheet SDS

Rabbit Anti-H1-0 Recombinant Antibody (
1C7) (V2LY-0725-LY741)

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Target: H1-0
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1C7
Application*: E
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (CBFYH-3496) (CBMAB-H4046-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Cattle
Clone: CBFYH-3496
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0567) (CBMAB-H1453-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBFYH-0567
Application*: WB, P, C, IF, IC, GS, F
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0566) (CBMAB-H1452-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human, Frog
Clone: CBFYH-0566
Application*: WB, P, C, GS, F, IF
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (OSHT-2) (CBMAB-H1450-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: OSHT-2
Application*: P, IF, F
Datasheet SDS

Rabbit Anti-H1-0 Monoclonal Antibody (CBFYH-3000) (CBMAB-H1449-FY)

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Target: H1-0
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-3000
Application*: P, IF, F
Datasheet SDS

Mouse Anti-H1-0 Monoclonal Antibody (CBFYH-2999) (CBMAB-H1448-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYH-2999
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (AE-4) (CBMAB-H1445-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: AE-4
Application*: F, P, IF
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0563) (CBMAB-H0614-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0563
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0564) (CBMAB-H0264-FY)

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Target: H1-0
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0564
Application*: F, IF, P, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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