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H1-0

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family.

Full Name

H1.0 linker histone

Alternative Names

H10; H1.0; H1F0; H1FV

Function

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

Biological Process

Chromosome condensation
Heterochromatin formation
Negative regulation of DNA recombination
Nucleosome assembly
Positive regulation of transcription regulatory region DNA binding

Cellular Location

Nucleus
Chromosome
Note: The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

PTM

Phosphorylated on Ser-17 in RNA edited version.
ADP-ribosylated on Ser-104 in response to DNA damage.

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Anti-H1-0 antibodies

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Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0565) (CBMAB-H1451-FY)

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Target: H1-0

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Cattle, Frog

Clone: CBFYH-0565

Application*: WB, P, IP, IF, F

Rabbit Anti-H1-0 Recombinant Antibody (CBNH-063) (V2LY-0226-LY2419)

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Target: H1-0

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBNH-063

Application*: WB, IF, P

Mouse Anti-H1-0 Recombinant Antibody (CBFYH-0564) (V2LY-0226-LY2409)

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Target: H1-0

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBFYH-0564

Application*: WB, IH, F

Rabbit Anti-H1-0 Recombinant Antibody (
1C7) (V2LY-0725-LY741)

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Target: H1-0

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 1C7

Application*: E

Rabbit Anti-H1-0 Recombinant Antibody (CBFYH-3000) (CBMAB-H1449-FY)

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Target: H1-0

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYH-3000

Application*: WB, P

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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