HHLA2

This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants.

Full Name

Herv-H Ltr-Associating 2

Function

Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Biological Process

Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Regulation of cytokine production Source: GO_Central
T cell costimulation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central

Cellular Location

Membrane

Topology

Helical: 345-365

Anti-HHLA2 antibodies

Mouse Anti-HHLA2 Recombinant Antibody (CBYY-1764) (CBMAB-2113-YY)

Datasheet

SDS

Target: HHLA2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1764

Application*: F, MC

Mouse Anti-HHLA2 Recombinant Antibody (CBYY-1762) (CBMAB-2111-YY)

Datasheet

SDS

Target: HHLA2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1762

Application*: B, IC, F

Rat Anti-HHLA2 Recombinant Antibody (CBYY-1067) (CBMAB-1071-YY)

Datasheet

SDS

Target: HHLA2

Host: Rat

Specificity: Mouse

Clone: CBYY-1067

Application*: IC, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)