HHLA2

This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants.
Full Name
Herv-H Ltr-Associating 2
Function
Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Biological Process
Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Regulation of cytokine production Source: GO_Central
T cell costimulation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Helical: 345-365
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Anti-HHLA2 antibodies

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Mouse Anti-HHLA2 Recombinant Antibody (CBYY-1764) (CBMAB-2113-YY)

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Target: HHLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1764
Application*: F, MC
Datasheet SDS

Mouse Anti-HHLA2 Recombinant Antibody (CBYY-1762) (CBMAB-2111-YY)

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Target: HHLA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1762
Application*: B, IC, F
Datasheet SDS

Rat Anti-HHLA2 Recombinant Antibody (CBYY-1067) (CBMAB-1071-YY)

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Target: HHLA2
Host: Rat
Specificity: Mouse
Clone: CBYY-1067
Application*: IC, WB
Datasheet SDS

Human Recombinant HHLA2 protein, His Tag (V2LY-0526-LY2280)

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Target: HHLA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: His Tag
Datasheet SDS

Human Recombinant HHLA2 protein, Biotin Conjugated, hFc & AVI Tag (V2LY-0526-LY2279)

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Target: HHLA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: hFc & AVI Tag
Datasheet SDS

Human Recombinant HHLA2 protein, ECD, Biotin Conjugated, His Tag (V2LY-0526-LY2278)

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Target: HHLA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: His Tag
Datasheet SDS

Human Recombinant HHLA2 protein, ECD, hFc Tag (V2LY-0526-LY2277)

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Target: HHLA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: hFc Tag
Datasheet SDS

Cynomolgus Recombinant HHLA2 protein, His Tag (V2LY-0526-LY1389)

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Target: HHLA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-345
Tag: His Tag
Datasheet SDS

Cynomolgus Recombinant HHLA2 protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY1388)

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Target: HHLA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-345
Tag: His & AVI Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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