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Rat Anti-HHLA2 Recombinant Antibody (CBYY-1067) (CBMAB-1071-YY)

This product is rat antibody that recognizes HHLA2. The antibody CBYY-1067 can be used for immunoassay techniques such as: ICC, WB
See all HHLA2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-1067
Application
ICC, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse B7-H5
Specificity
Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Herv-H Ltr-Associating 2
Introduction
This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Entrez Gene ID
108352332
Alternative Names
HERV-H LTR-Associating 2; Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2; HERV-H LTR-Associating Protein 2; B7-H5; B7-H7; B7H7; B7y;
Function
Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Biological Process
Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Regulation of cytokine production Source: GO_Central
T cell costimulation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Helical: 345-365

Mortezaee, K. (2023). HHLA2 immune-regulatory roles in cancer. Biomedicine & Pharmacotherapy, 162, 114639.

Li, Y., Lv, C., Yu, Y., Wu, B., Zhang, Y., Lang, Q., ... & Tian, Y. (2022). KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy. Journal of advanced research.

Wei, Y., Ren, X., Galbo Jr, P. M., Moerdler, S., Wang, H., Sica, R. A., ... & Zang, X. (2021). KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target. Science immunology, 6(61), eabf9792.

Bhatt, R. S., Berjis, A., Konge, J. C., Mahoney, K. M., Klee, A. N., Freeman, S. S., ... & Freeman, G. J. (2021). KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1. Cancer immunology research, 9(2), 156-169.

Luo, M., Lin, Y., Liang, R., Li, Y., & Ge, L. (2021). Clinical significance of the HHLA2 protein in hepatocellular carcinoma and the tumor microenvironment. Journal of Inflammation Research, 14, 4217.

Zhou, Q. H., Li, K. W., Chen, X., He, H. X., Peng, S. M., Peng, S. R., ... & Huang, H. (2020). HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma. Journal for immunotherapy of cancer, 8(1).

Chen, L., Zhu, D., Feng, J., Zhou, Y., Wang, Q., Feng, H., ... & Jiang, J. (2019). Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients. Cancer cell international, 19(1), 1-12.

Jing, C. Y., Fu, Y. P., Yi, Y., Zhang, M. X., Zheng, S. S., Huang, J. L., ... & Zhang, B. H. (2019). HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1. Journal for Immunotherapy of Cancer, 7, 1-11.

Shimonosono, M., Arigami, T., Yanagita, S., Matsushita, D., Uchikado, Y., Kijima, Y., ... & Natsugoe, S. (2018). The association of human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) expression with gastric cancer prognosis. Oncotarget, 9(31), 22069.

Zhu, Z., & Dong, W. (2018). Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma. OncoTargets and therapy, 1563-1570.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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