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ICOSLG

ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Inclusion Body Myositis and Immunodeficiency With Hyper-Igm, Type 2. Among its related pathways are Allograft rejection and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.

Full Name

Inducible T Cell Costimulator Ligand

Function

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Biological Process

Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB-KW
Defense response Source: UniProtKB
Hyperosmotic response Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Regulation of cytokine production Source: GO_Central
Signal transduction Source: UniProtKB
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 19-256
Helical: 257-277
Cytoplasmic: 278-302

Anti-ICOSLG antibodies

Mouse Anti-ICOSLG Recombinant Antibody (CBWJC-2185) (CBMAB-C2956WJ)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-2185

Application*: E

Mouse Anti-ICOSLG Recombinant Antibody (CBWJC-3790) (CBMAB-C5058WJ)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3790

Application*: E, F

Rat Anti-ICOSLG Recombinant Antibody (HK5.3) (CBMAB-1021-LY)

SDS

Target: ICOSLG

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: HK5.3

Application*: N

Mouse Anti-ICOSLG Recombinant Antibody (1E2) (CBMAB-A4190-LY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E2

Application*: WB, E

Mouse Anti-ICOSLG Recombinant Antibody (2D3) (CBMAB-C0862-LY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2D3

Application*: F

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1715) (CBMAB-2064-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-1715

Application*: WB, N

Rat Anti-ICOSLG Recombinant Antibody (CBYY-1745) (CBMAB-2094-YY)

SDS

Target: ICOSLG

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYY-1745

Application*: F, MC

Rat Anti-ICOSLG Recombinant Antibody (CBYY-1746) (CBMAB-2095-YY)

SDS

Target: ICOSLG

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYY-1746

Application*: F, IC, MC

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1989) (CBMAB-2338-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-1989

Application*: F, P

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I0091) (CBMAB-I0232-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0091

Application*: F

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I0950) (CBMAB-I2118-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0950

Application*: E, ED

Rat Anti-ICOSLG Recombinant Antibody (CBYY-I0988) (CBMAB-I2156-YY)

SDS

Target: ICOSLG

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYY-I0988

Application*: F

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I1164) (CBMAB-I2332-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1164

Application*: F

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I1901) (CBMAB-I3071-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1901

Application*: WB

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I1972) (CBMAB-I3142-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I1972

Application*: WB, IH

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I1995) (CBMAB-I3165-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1995

Application*: WB, IH

Mouse Anti-ICOSLG Recombinant Antibody (MIH12) (CBMAB-C1795-CQ)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MIH12

Application*: F

Mouse Anti-ICOSLG Recombinant Antibody (CBXC-0654) (CBMAB-C3221-CQ)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0654

Application*: E, WB

Mouse Anti-ICOSLG Recombinant Antibody (CBXC-0653) (CBMAB-C3740-CQ)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0653

Application*: F, IH

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1068) (CBMAB-1072-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-1068

Application*: WB, N

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1069) (CBMAB-1073-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-1069

Application*: WB, IH

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1070) (CBMAB-1074-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-1070

Application*: E

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1071) (CBMAB-1075-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-1071

Application*: WB

Rat Anti-ICOSLG Recombinant Antibody (CBYY-1072) (CBMAB-1076-YY)

SDS

Target: ICOSLG

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-1072

Application*: F, B, MC

Mouse Anti-ICOSLG (C-Terminus) Recombinant Antibody (CBYY-1073) (CBMAB-1077-YY)

SDS

Target: ICOSLG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1073

Application*: WB, B

ICOSLG Matched Antibody Pair (583) (APMAB-583LY)

SDS

Target: ICOSLG

Specificity: Human

ICOSLG Matched Antibody Pair (582) (APMAB-582LY)

SDS

Target: ICOSLG

Specificity: Human

ICOSLG Matched Antibody Pair (581) (APMAB-581LY)

SDS

Target: ICOSLG

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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