ICOSLG
ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Inclusion Body Myositis and Immunodeficiency With Hyper-Igm, Type 2. Among its related pathways are Allograft rejection and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.
Full Name
Inducible T Cell Costimulator Ligand
Alternative Names
B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; KIAA0653; LICOS
Function
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB-KW
Defense response Source: UniProtKB
Hyperosmotic response Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Regulation of cytokine production Source: GO_Central
Signal transduction Source: UniProtKB
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
B cell activation Source: UniProtKB-KW
Defense response Source: UniProtKB
Hyperosmotic response Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Regulation of cytokine production Source: GO_Central
Signal transduction Source: UniProtKB
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 19-256
Helical: 257-277
Cytoplasmic: 278-302
Helical: 257-277
Cytoplasmic: 278-302
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Anti-ICOSLG antibodies
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CompareTarget: ICOSLG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: HK5.3
Application*: N
Target: ICOSLG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG90
Application*: B, F, In Vivo
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E2
Application*: WB, E
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2D3
Application*: F
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3609
Application*: F
Target: ICOSLG
Specificity: Human
Target: ICOSLG
Specificity: Human
Target: ICOSLG
Specificity: Human
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3790
Application*: E, F
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2185
Application*: E
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0653
Application*: F, IH
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0654
Application*: E, WB
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH12
Application*: F
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1995
Application*: WB, IH
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1972
Application*: WB, IH
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1901
Application*: WB
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1164
Application*: F
Target: ICOSLG
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0988
Application*: F
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0950
Application*: E, ED
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0091
Application*: F
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-1989
Application*: F, P
Target: ICOSLG
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1746
Application*: F, IC, MC
Target: ICOSLG
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1745
Application*: F, MC
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1715
Application*: WB, N
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1073
Application*: WB, B
Target: ICOSLG
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1072
Application*: F, B, MC
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1071
Application*: WB
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1070
Application*: E
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1069
Application*: WB, IH
Target: ICOSLG
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-1068
Application*: WB, N
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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