Rat Recombinant ICOSLG protein, hFc Tag (V2LY-0526-LY9170)

Name: Rat Recombinant ICOSLG protein, hFc Tag
SKU: V2LY-0526-LY9170
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

hFc Tag

Protein Construction

This product is Rat Recombinant ICOSLG protein, hFc Tag consist of Amino Acid: 1-261 and predicts a molecular mass of 53.6 kDa.

Molecule Mass

53.6 kDa

Sequence

Amino Acid: 1-261

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Inducible T Cell Costimulator Ligand

Alternative Names

B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; KIAA0653; LICOS

Function

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Biological Process

Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB-KW
Defense response Source: UniProtKB
Hyperosmotic response Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Regulation of cytokine production Source: GO_Central
Signal transduction Source: UniProtKB
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 19-256
Helical: 257-277
Cytoplasmic: 278-302

Zhang, Y., Wang, X. L., Liu, J. J., Qian, Z. Y., Pan, Z. Y., Song, N. P., ... & Zhang, X. (2023). ICOS/ICOSLG and PD-1 Co-Expression is Associated with the Progression of Colorectal Precancerous-Carcinoma Immune Microenvironment. Journal of Inflammation Research, 977-992.

Külp, M., Siemund, A. L., Larghero, P., Dietz, A., Alten, J., Cario, G., ... & Marschalek, R. (2022). The immune checkpoint ICOSLG is a relapse-predicting biomarker and therapeutic target in infant t (4; 11) acute lymphoblastic leukemia. Iscience, 25(7).

Zhang, C., Wang, F., Sun, N., Zhang, Z., Zhang, G., Zhang, Z., ... & He, J. (2022). The combination of novel immune checkpoints HHLA2 and ICOSLG: A new system to predict survival and immune features in esophageal squamous cell carcinoma. Genes & diseases, 9(2), 415-428.

Külp, M., Larghero, P., Dietz, A., Cario, G., Eckert, C., Caye-Eude, A., ... & Marschalek, R. (2022). The immune checkpoint ICOSLG is a relapse-predicting biomarker and therapeutic target in infant t (4; 11) ALL. Klinische Pädiatrie, 234(03), 174-175.

Roussel, L., & Vinh, D. C. (2021). ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency. Current Opinion in Immunology, 72, 21-26.

Holst, C. B., Christensen, I. J., Vitting-Seerup, K., Skjøth-Rasmussen, J., Hamerlik, P., Poulsen, H. S., & Johansen, J. S. (2021). Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma. Neuro-Oncology Advances, 3(1), vdab072.

Külp, M., Siemund, A. L., Meyer, C., Larghero, P., Dietz, A., Alten, J., ... & Marschalek, R. (2021). Implication of ICOSLG on Relapse in Infant T (4; 11) Acute Lymphoblastic Leukemia. Blood, 138(Supplement 1), 3481-3481.

Iwata, R., Hyoung Lee, J., Hayashi, M., Dianzani, U., Ofune, K., Maruyama, M., ... & Asai, A. (2020). ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma. Neuro-oncology, 22(3), 333-344.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ICOSLG protein, ECD, His Tag (CAT#: V2LY-0526-LY2248)

Human Recombinant ICOSLG proteinECD (CAT#: V2LY-0526-LY2249)

Human Recombinant ICOSLG protein, hFc Tag (CAT#: V2LY-0526-LY2250)

Human Recombinant ICOSLG protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY2251)

Mouse Recombinant ICOSLG protein, His & hFc Tag (CAT#: V2LY-0526-LY7842)

Mouse Recombinant ICOSLG protein, His Tag (CAT#: V2LY-0526-LY7843)

Mouse Recombinant ICOSLG protein, His Tag-1 (CAT#: V2LY-0526-LY7844)

Rat Recombinant ICOSLG protein, His Tag (CAT#: V2LY-0526-LY9171)

Cynomolgus Recombinant ICOSLG protein, ECD, His Tag (CAT#: V2LY-0526-LY1380)

Cynomolgus Recombinant ICOSLG protein, hFc Tag (CAT#: V2LY-0526-LY1381)

Antibody Pairs

ICOSLG Matched Antibody Pair (581) (CAT#: APMAB-581LY)

ICOSLG Matched Antibody Pair (582) (CAT#: APMAB-582LY)

ICOSLG Matched Antibody Pair (583) (CAT#: APMAB-583LY)

Related Products

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I1972) (CAT#: CBMAB-I3142-YY)

Mouse Recombinant ICOSLG protein, His Tag-1 (CAT#: V2LY-0526-LY7844)

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1069) (CAT#: CBMAB-1073-YY)

Human Recombinant ICOSLG protein, hFc Tag (CAT#: V2LY-0526-LY2250)

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-1989) (CAT#: CBMAB-2338-YY)

Mouse Anti-ICOSLG Recombinant Antibody (CBYY-I1164) (CAT#: CBMAB-I2332-YY)

ICOSLG Matched Antibody Pair (583) (CAT#: APMAB-583LY)

Rat Anti-ICOSLG Recombinant Antibody (CBYY-1746) (CAT#: CBMAB-2095-YY)

Mouse Anti-ICOSLG Recombinant Antibody (2D3) (CAT#: CBMAB-C0862-LY)

Rat Anti-ICOSLG Recombinant Antibody (CBYY-1072) (CAT#: CBMAB-1076-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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