IGFBP1
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Full Name
insulin like growth factor binding protein 1
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Biological Process
Aging Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl
Cellular Location
Secreted
PTM
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
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Anti-IGFBP1 antibodies
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CompareTarget: IGFBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1438
Application*: E, WB
Target: IGFBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1597
Application*: IHC: 1:50~1:100 ELISA: 1:5000
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: A435
Application*: ELISA, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A434
Application*: ICC, IHC, IP, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0715
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CB281A
Application*: ELISA, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F9
Application*: WB, E
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 1E1B2
Application*: E, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1897
Application*: WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1439
Application*: E, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1371
Application*: N, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1158
Application*: WB, IH
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 7973
Application*: E, C, P
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB1836
Application*: E, WB
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB2576
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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