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IGFBP1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Full Name
insulin like growth factor binding protein 1
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Biological Process
Aging Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl
Cellular Location
Secreted
PTM
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.

Anti-IGFBP1 antibodies

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Recombinant Mouse Anti-Insulin Like Growth Factor Binding Protein 1 (IGFBP-1) Antibody (CB2576) (CBMAB-MD876-LY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB2576
Application*: E, WB

Recombinant Mouse Anti-Insulin Like Growth Factor Binding Protein 1 (IGFBP-1) Antibody (CB1836) (CBMAB-MD877-LY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB1836
Application*: E, WB

Mouse Anti-IGFBP1 Recombinant Antibody (1E1B2) (CBMAB-R4289-CN)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 1E1B2
Application*: E, WB

Mouse Anti-IGFBP1 Recombinant Antibody (2F9) (CBMAB-A4298-LY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F9
Application*: WB, E

Mouse Anti-IGFBP1 Recombinant Antibody (CB281A) (CBMAB-CA281LY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CB281A
Application*: ELISA, WB

Mouse Anti-IGFBP1 Monoclonal Antibody (CBFYR0715) (CBMAB-R0715-FY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0715

Mouse Anti-IGFBP1 Recombinant Antibody (A434) (CBMAB-AP3832LY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A434
Application*: ICC, IHC, IP, WB

Mouse Anti-IGFBP1 Recombinant Antibody (A435) (CBMAB-AP3617LY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: A435
Application*: ELISA, WB

Rabbit Anti-IGFBP1 Recombinant Antibody (EG1597) (CBMAB-EN1910-LY)

Datasheet SDS
Target: IGFBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1597
Application*: IHC: 1:50~1:100 ELISA: 1:5000

Mouse Anti-IGFBP1 Recombinant Antibody (7973) (CBMAB-I1644-YY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 7973
Application*: E, C, P

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1158) (CBMAB-I2326-YY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1158
Application*: WB, IH

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1371) (CBMAB-I2541-YY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1371
Application*: N, WB

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1438) (CBMAB-I2608-YY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1438
Application*: E, WB

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1439) (CBMAB-I2609-YY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1439
Application*: E, WB

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1897) (CBMAB-I3067-YY)

Datasheet SDS
Target: IGFBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1897
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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