Rhesus Recombinant IGFBP1 protein, His Tag (V2LY-0526-LY9730)

Name: Rhesus Recombinant IGFBP1 protein, His Tag
SKU: V2LY-0526-LY9730
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rhesus

Tag

His Tag

Protein Construction

This product is Rhesus Recombinant IGFBP1 protein, His Tag consist of Amino Acid: 23-281 and predicts a molecular mass of 26.7 kDa.

Molecule Mass

26.7 kDa

Sequence

Amino Acid: 23-281

Species

Rhesus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>98% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

insulin like growth factor binding protein 1

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Biological Process

Aging Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl

Cellular Location

Secreted

PTM

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.

Zhang, B., Hong, C. Q., Lin, Y. W., Luo, Y., Ding, T. Y., Xu, Y. W., ... & Wu, F. C. (2023). Association between IGFBP1 expression and cancer risk: A systematic review and meta-analysis. Heliyon.

Tang, Q., Zhou, Q., Li, J., Yang, X., Wang, R., Wang, X., ... & Wang, S. (2023). Solamargine enhanced gefitinib anti-tumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis, bgad028.

Maruyama, T., Saito, K., Higurashi, M., Ishikawa, F., Kohno, Y., Mori, K., & Shibanuma, M. (2023). HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells. Cancer Science, 114(1), 152.

Meyer, N. M., Kabisch, S., Dambeck, U., Honsek, C., Kemper, M., Gerbracht, C., ... & Pfeiffer, A. F. (2022). Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients. European Journal of Endocrinology, 187(4), 555-565.

Xu, T., Gao, S., Liu, J., Huang, Y., Chen, K., & Zhang, X. (2021). MMP9 and IGFBP1 regulate tumor immune and drive tumor progression in clear cell renal cell carcinoma. Journal of Cancer, 12(8), 2243.

Gęca, T., & Kwaśniewska, A. (2020). The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study. Journal of clinical medicine, 9(10), 3256.

Lee, S. Y., Fam, K. D., Chia, K. L., Yap, M. M., Goh, J., Yeo, K. P., ... & Lim, C. L. (2020). Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults. Experimental Physiology, 105(4), 622-631.

Wu, X., Zheng, W., Jin, P., Hu, J., & Zhou, Q. (2019). Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. International Journal of Molecular Medicine, 44(5), 1921-1931.

Sato, Y., Inokuchi, M., Takagi, Y., & Kojima, K. (2019). IGFBP1 is a predictive factor for haematogenous metastasis in patients with gastric cancer. Anticancer Research, 39(6), 2829-2837.

Zheng, F., Tang, Q., Zheng, X. H., Wu, J., Huang, H., Zhang, H., & Hann, S. S. (2018). Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. Experimental & molecular medicine, 50(9), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IGFBP1 protein, His Tag (CAT#: V2LY-0526-LY1261)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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