Mouse Anti-IGFBP1 Recombinant Antibody (2F9) (CBMAB-A4298-LY)

Name: Mouse Anti-IGFBP1 Recombinant Antibody (2F9)
SKU: CBMAB-A4298-LY
Rating: 5 (1 reviews)

See all IGFBP1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F9

Application

WB, ELISA

Immunogen

IGFBP1 (NP_000587, 160 a.a. ~ 259 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

insulin like growth factor binding protein 1

Introduction

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq]

Entrez Gene ID

3484

UniProt ID

P08833

Alternative Names

AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Biological Process

Aging Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl

Cellular Location

Secreted

PTM

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.

Zhang, B., Hong, C. Q., Lin, Y. W., Luo, Y., Ding, T. Y., Xu, Y. W., ... & Wu, F. C. (2023). Association between IGFBP1 expression and cancer risk: A systematic review and meta-analysis. Heliyon.

Tang, Q., Zhou, Q., Li, J., Yang, X., Wang, R., Wang, X., ... & Wang, S. (2023). Solamargine enhanced gefitinib anti-tumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis, bgad028.

Maruyama, T., Saito, K., Higurashi, M., Ishikawa, F., Kohno, Y., Mori, K., & Shibanuma, M. (2023). HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells. Cancer Science, 114(1), 152.

Meyer, N. M., Kabisch, S., Dambeck, U., Honsek, C., Kemper, M., Gerbracht, C., ... & Pfeiffer, A. F. (2022). Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients. European Journal of Endocrinology, 187(4), 555-565.

Xu, T., Gao, S., Liu, J., Huang, Y., Chen, K., & Zhang, X. (2021). MMP9 and IGFBP1 regulate tumor immune and drive tumor progression in clear cell renal cell carcinoma. Journal of Cancer, 12(8), 2243.

Gęca, T., & Kwaśniewska, A. (2020). The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study. Journal of clinical medicine, 9(10), 3256.

Lee, S. Y., Fam, K. D., Chia, K. L., Yap, M. M., Goh, J., Yeo, K. P., ... & Lim, C. L. (2020). Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults. Experimental Physiology, 105(4), 622-631.

Wu, X., Zheng, W., Jin, P., Hu, J., & Zhou, Q. (2019). Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. International Journal of Molecular Medicine, 44(5), 1921-1931.

Sato, Y., Inokuchi, M., Takagi, Y., & Kojima, K. (2019). IGFBP1 is a predictive factor for haematogenous metastasis in patients with gastric cancer. Anticancer Research, 39(6), 2829-2837.

Zheng, F., Tang, Q., Zheng, X. H., Wu, J., Huang, H., Zhang, H., & Hann, S. S. (2018). Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. Experimental & molecular medicine, 50(9), 1-14.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-IGFBP1 Recombinant Antibody (2F9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Recombinant Mouse Anti-Insulin Like Growth Factor Binding Protein 1 (IGFBP-1) Antibody (CB2576) (CAT#: CBMAB-MD876-LY)

Mouse Anti-IGFBP1 Recombinant Antibody (1E1B2) (CAT#: CBMAB-R4289-CN)

Mouse Anti-IGFBP1 Monoclonal Antibody (CBFYR0715) (CAT#: CBMAB-R0715-FY)

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1158) (CAT#: CBMAB-I2326-YY)

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1438) (CAT#: CBMAB-I2608-YY)

Mouse Anti-IGFBP1 Recombinant Antibody (CB281A) (CAT#: CBMAB-CA281LY)

Rabbit Anti-IGFBP1 Recombinant Antibody (EG1597) (CAT#: CBMAB-EN1910-LY)

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1371) (CAT#: CBMAB-I2541-YY)

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1897) (CAT#: CBMAB-I3067-YY)

Recombinant Mouse Anti-Insulin Like Growth Factor Binding Protein 1 (IGFBP-1) Antibody (CB1836) (CAT#: CBMAB-MD877-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry