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Mouse Anti-IGFBP1 Recombinant Antibody (2F9) (CBMAB-A4298-LY)

The product is antibody recognizes IGFBP1. The antibody 2F9 immunoassay techniques such as: WB, ELISA.
See all IGFBP1 antibodies
Published Data
Fig. 1 Total (T), cytosolic (C), and mitochondrial (M) liver extracts were examined by Western blot for the proteins indicated, following a 90-min treatment of the animals with cisplatin or Fas mAb. The internal control BCL-xL is present in both cytosolic and mitochondrial fractions.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IGFBP1 (NP_000587, 160 a.a. ~ 259 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
insulin like growth factor binding protein 1
Introduction
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq]
Entrez Gene ID
3484
UniProt ID
P08833
Alternative Names
AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Biological Process
Aging Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl
Cellular Location
Secreted
PTM
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.

Zhang, B., Hong, C. Q., Lin, Y. W., Luo, Y., Ding, T. Y., Xu, Y. W., ... & Wu, F. C. (2023). Association between IGFBP1 expression and cancer risk: A systematic review and meta-analysis. Heliyon.

Tang, Q., Zhou, Q., Li, J., Yang, X., Wang, R., Wang, X., ... & Wang, S. (2023). Solamargine enhanced gefitinib anti-tumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis, bgad028.

Maruyama, T., Saito, K., Higurashi, M., Ishikawa, F., Kohno, Y., Mori, K., & Shibanuma, M. (2023). HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells. Cancer Science, 114(1), 152.

Meyer, N. M., Kabisch, S., Dambeck, U., Honsek, C., Kemper, M., Gerbracht, C., ... & Pfeiffer, A. F. (2022). Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients. European Journal of Endocrinology, 187(4), 555-565.

Xu, T., Gao, S., Liu, J., Huang, Y., Chen, K., & Zhang, X. (2021). MMP9 and IGFBP1 regulate tumor immune and drive tumor progression in clear cell renal cell carcinoma. Journal of Cancer, 12(8), 2243.

Gęca, T., & Kwaśniewska, A. (2020). The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study. Journal of clinical medicine, 9(10), 3256.

Lee, S. Y., Fam, K. D., Chia, K. L., Yap, M. M., Goh, J., Yeo, K. P., ... & Lim, C. L. (2020). Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults. Experimental Physiology, 105(4), 622-631.

Wu, X., Zheng, W., Jin, P., Hu, J., & Zhou, Q. (2019). Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. International Journal of Molecular Medicine, 44(5), 1921-1931.

Sato, Y., Inokuchi, M., Takagi, Y., & Kojima, K. (2019). IGFBP1 is a predictive factor for haematogenous metastasis in patients with gastric cancer. Anticancer Research, 39(6), 2829-2837.

Zheng, F., Tang, Q., Zheng, X. H., Wu, J., Huang, H., Zhang, H., & Hann, S. S. (2018). Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. Experimental & molecular medicine, 50(9), 1-14.

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For research use only. Not intended for any clinical use.

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