Rat Igfbp1 ELISA Kit (V2LY-0626-LY1104)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0052 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
29.7 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
insulin like growth factor binding protein 1
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Biological Process
Aging Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Tissue regeneration Source: Ensembl
Cellular Location
Secreted
PTM
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.

Zhang, B., Hong, C. Q., Lin, Y. W., Luo, Y., Ding, T. Y., Xu, Y. W., ... & Wu, F. C. (2023). Association between IGFBP1 expression and cancer risk: A systematic review and meta-analysis. Heliyon.

Tang, Q., Zhou, Q., Li, J., Yang, X., Wang, R., Wang, X., ... & Wang, S. (2023). Solamargine enhanced gefitinib anti-tumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis, bgad028.

Maruyama, T., Saito, K., Higurashi, M., Ishikawa, F., Kohno, Y., Mori, K., & Shibanuma, M. (2023). HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells. Cancer Science, 114(1), 152.

Meyer, N. M., Kabisch, S., Dambeck, U., Honsek, C., Kemper, M., Gerbracht, C., ... & Pfeiffer, A. F. (2022). Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients. European Journal of Endocrinology, 187(4), 555-565.

Xu, T., Gao, S., Liu, J., Huang, Y., Chen, K., & Zhang, X. (2021). MMP9 and IGFBP1 regulate tumor immune and drive tumor progression in clear cell renal cell carcinoma. Journal of Cancer, 12(8), 2243.

Gęca, T., & Kwaśniewska, A. (2020). The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study. Journal of clinical medicine, 9(10), 3256.

Lee, S. Y., Fam, K. D., Chia, K. L., Yap, M. M., Goh, J., Yeo, K. P., ... & Lim, C. L. (2020). Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults. Experimental Physiology, 105(4), 622-631.

Wu, X., Zheng, W., Jin, P., Hu, J., & Zhou, Q. (2019). Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. International Journal of Molecular Medicine, 44(5), 1921-1931.

Sato, Y., Inokuchi, M., Takagi, Y., & Kojima, K. (2019). IGFBP1 is a predictive factor for haematogenous metastasis in patients with gastric cancer. Anticancer Research, 39(6), 2829-2837.

Zheng, F., Tang, Q., Zheng, X. H., Wu, J., Huang, H., Zhang, H., & Hann, S. S. (2018). Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. Experimental & molecular medicine, 50(9), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Igfbp1 ELISA Kit (CAT#: V2LY-0626-LY1106)

Human IGFBP1 ELISA Kit (CAT#: V2LY-0626-LY3969)

Human IGFBP1 ELISA Kit (2) (CAT#: V2LY-0626-LY854)

Pig IGFBP1 ELISA Kit (CAT#: V2LY-0626-LY982)

Canine Recombinant IGFBP1 protein, His Tag (CAT#: V2LY-0526-LY1261)

Rhesus Recombinant IGFBP1 protein, His Tag (CAT#: V2LY-0526-LY9730)

Related Products

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1158) (CAT#: CBMAB-I2326-YY)

Human IGFBP1 ELISA Kit (2) (CAT#: V2LY-0626-LY854)

Mouse Anti-IGFBP1 Recombinant Antibody (1E1B2) (CAT#: CBMAB-R4289-CN)

Recombinant Mouse Anti-Insulin Like Growth Factor Binding Protein 1 (IGFBP-1) Antibody (CB2576) (CAT#: CBMAB-MD876-LY)

Mouse Igfbp1 ELISA Kit (CAT#: V2LY-0626-LY1106)

Human IGFBP1 ELISA Kit (CAT#: V2LY-0626-LY3969)

Pig IGFBP1 ELISA Kit (CAT#: V2LY-0626-LY982)

Mouse Anti-IGFBP1 Recombinant Antibody (CBYY-I1438) (CAT#: CBMAB-I2608-YY)

Mouse Anti-IGFBP1 Recombinant Antibody (A435) (CAT#: CBMAB-AP3617LY)

Canine Recombinant IGFBP1 protein, His Tag (CAT#: V2LY-0526-LY1261)

Isotype control

For research use only. Not intended for any clinical use.

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