IL1RN
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
Full Name
Interleukin 1 Receptor Antagonist
Function
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Cellular Location
Isoform 1: Secreted
Isoform 2&3&4: Cytoplasm
Isoform 2&3&4: Cytoplasm
Involvement in disease
Microvascular complications of diabetes 4 (MVCD4):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Interleukin 1 receptor antagonist deficiency (DIRA):
A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Interleukin 1 receptor antagonist deficiency (DIRA):
A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.
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Anti-IL1RN antibodies
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CompareTarget: IL1RN
Specificity: Human
Target: IL1RN
Specificity: Human
Target: IL1RN
Specificity: Human
Target: IL1RN
Specificity: Human
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb151
Application*: IHC-F, Immuno assays, WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 20D8
Application*: WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S14
Application*: WB, E
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0094
Application*: C, IA, WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I2019
Application*: WB, IH
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1981
Application*: WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1978
Application*: WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1976
Application*: WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1958
Application*: WB, IH
Target: IL1RN
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1089
Application*: WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1078
Application*: E
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1008
Application*: WB
Target: IL1RN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I0966
Application*: P
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AS17
Application*: F, IS, E
Target: IL1RN
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0696
Application*: WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F11H11
Application*: E, WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0279
Application*: E
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D11
Application*: E, WB, C, C, F, R
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1H5
Application*: E, IP, WB
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10309
Application*: N, E
Target: IL1RN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I0167
Application*: F, IF, IF
Target: IL1RN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0164
Application*: IF, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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