Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1981) (CBMAB-I3151-YY)

Name: Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1981)
SKU: CBMAB-I3151-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1981

Application

Immunogen

Full length human recombinant protein of human IL1RN (NP_776215)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 1 Receptor Antagonist

Introduction

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Entrez Gene ID

3557

UniProt ID

P18510

Alternative Names

Interleukin 1 Receptor Antagonist

Function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Cellular Location

Isoform 1: Secreted
Isoform 2&3&4: Cytoplasm

Involvement in disease

Microvascular complications of diabetes 4 (MVCD4):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Interleukin 1 receptor antagonist deficiency (DIRA):
A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.

Attur, M. G., Petrilli, C. M., Adhikari, S., Iturrate, E., Li, X., Tuminello, S., ... & Abramson, S. B. (2023). Interleukin-1 receptor antagonist gene (IL1RN) variants modulate the cytokine release syndrome and mortality of SARS-CoV-2. medRxiv, 2023-01.

Rokni, M., Sarhadi, M., Heidari Nia, M., Mohamed Khosroshahi, L., Asghari, S., Sargazi, S., ... & Saravani, R. (2022). Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population. Cell Biology International, 46(7), 1109-1127.

Wang, Q., Huang, X., Zhou, S., Ding, Y., Wang, H., Jiang, W., & Xu, M. (2022). IL1RN and PRRX1 as a prognostic biomarker correlated with immune infiltrates in colorectal cancer: evidence from bioinformatic analysis. International Journal of Genomics, 2022.

Maculewicz, E., Antkowiak, B., Antkowiak, O., Borecka, A., Mastalerz, A., Leońska-Duniec, A., ... & Cięszczyk, P. (2022). The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters. BMC genomics, 23(1), 1-12.

Pardeo, M., Rossi, M. N., Pires Marafon, D., Sacco, E., Bracaglia, C., Passarelli, C., ... & De Benedetti, F. (2021). Early treatment and IL1RN single‐nucleotide polymorphisms affect response to anakinra in systemic juvenile idiopathic arthritis. Arthritis & Rheumatology, 73(6), 1053-1061.

Li, J., Zeng, X., & Wang, W. (2021). miR‑122‑5p downregulation attenuates lipopolysaccharide‑induced acute lung injury by targeting IL1RN. Experimental and therapeutic medicine, 22(5), 1-10.

Attur, M., Zhou, H., Samuels, J., Krasnokutsky, S., Yau, M., Scher, J. U., ... & Abramson, S. B. (2020). Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease. Annals of the Rheumatic Diseases, 79(3), 400-407.

Kuemmerle-Deschner, J. B., Welzel, T., Hoertnagel, K., Tsiflikas, I., Hospach, A., Liu, X., ... & Weber, A. N. (2020). New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation. Rheumatology, 59(11), 3259-3263.

Teresa, F., Serra, N., Capra, G., Mascarella, C., Gagliardi, C., Di Carlo, P., ... & Giammanco, A. (2019). Helicobacter pylori and epstein–barr virus infection in gastric diseases: correlation with IL-10 and IL1RN polymorphism. Journal of oncology, 2019.

Arthur, V. L., Shuldiner, E., Remmers, E. F., Hinks, A., Grom, A. A., Foell, D., ... & Davidson, J. (2018). IL1RN variation influences both disease susceptibility and response to recombinant human interleukin‐1 receptor antagonist therapy in systemic juvenile idiopathic arthritis. Arthritis & Rheumatology, 70(8), 1319-1330.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

IL1RN Matched Antibody Pair (628) (CAT#: APMAB-628LY)

IL1RN Matched Antibody Pair (629) (CAT#: APMAB-629LY)

IL1RN Matched Antibody Pair (630) (CAT#: APMAB-630LY)

IL1RN Matched Antibody Pair (631) (CAT#: APMAB-631LY)

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IL1RN Matched Antibody Pair (631) (CAT#: APMAB-631LY)

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Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1008) (CAT#: CBMAB-I2176-YY)

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1958) (CAT#: CBMAB-I3128-YY)

IL1RN Matched Antibody Pair (628) (CAT#: APMAB-628LY)

Isotype control

For research use only. Not intended for any clinical use.

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