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Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1078) (CBMAB-I2246-YY)

This product is Mouse antibody that recognizes IL1RN. The antibody CBYY-I1078 can be used for immunoassay techniques such as: ELISA
See all IL1RN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I1078
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.5
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 1 Receptor Antagonist
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Entrez Gene ID
3557
UniProt ID
P18510
Alternative Names
Interleukin 1 Receptor Antagonist
Function
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Cellular Location
Isoform 1: Secreted
Isoform 2&3&4: Cytoplasm
Involvement in disease
Microvascular complications of diabetes 4 (MVCD4):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Interleukin 1 receptor antagonist deficiency (DIRA):
A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.

Attur, M. G., Petrilli, C. M., Adhikari, S., Iturrate, E., Li, X., Tuminello, S., ... & Abramson, S. B. (2023). Interleukin-1 receptor antagonist gene (IL1RN) variants modulate the cytokine release syndrome and mortality of SARS-CoV-2. medRxiv, 2023-01.

Rokni, M., Sarhadi, M., Heidari Nia, M., Mohamed Khosroshahi, L., Asghari, S., Sargazi, S., ... & Saravani, R. (2022). Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population. Cell Biology International, 46(7), 1109-1127.

Wang, Q., Huang, X., Zhou, S., Ding, Y., Wang, H., Jiang, W., & Xu, M. (2022). IL1RN and PRRX1 as a prognostic biomarker correlated with immune infiltrates in colorectal cancer: evidence from bioinformatic analysis. International Journal of Genomics, 2022.

Maculewicz, E., Antkowiak, B., Antkowiak, O., Borecka, A., Mastalerz, A., Leońska-Duniec, A., ... & Cięszczyk, P. (2022). The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters. BMC genomics, 23(1), 1-12.

Pardeo, M., Rossi, M. N., Pires Marafon, D., Sacco, E., Bracaglia, C., Passarelli, C., ... & De Benedetti, F. (2021). Early treatment and IL1RN single‐nucleotide polymorphisms affect response to anakinra in systemic juvenile idiopathic arthritis. Arthritis & Rheumatology, 73(6), 1053-1061.

Li, J., Zeng, X., & Wang, W. (2021). miR‑122‑5p downregulation attenuates lipopolysaccharide‑induced acute lung injury by targeting IL1RN. Experimental and therapeutic medicine, 22(5), 1-10.

Attur, M., Zhou, H., Samuels, J., Krasnokutsky, S., Yau, M., Scher, J. U., ... & Abramson, S. B. (2020). Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease. Annals of the Rheumatic Diseases, 79(3), 400-407.

Kuemmerle-Deschner, J. B., Welzel, T., Hoertnagel, K., Tsiflikas, I., Hospach, A., Liu, X., ... & Weber, A. N. (2020). New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation. Rheumatology, 59(11), 3259-3263.

Teresa, F., Serra, N., Capra, G., Mascarella, C., Gagliardi, C., Di Carlo, P., ... & Giammanco, A. (2019). Helicobacter pylori and epstein–barr virus infection in gastric diseases: correlation with IL-10 and IL1RN polymorphism. Journal of oncology, 2019.

Arthur, V. L., Shuldiner, E., Remmers, E. F., Hinks, A., Grom, A. A., Foell, D., ... & Davidson, J. (2018). IL1RN variation influences both disease susceptibility and response to recombinant human interleukin‐1 receptor antagonist therapy in systemic juvenile idiopathic arthritis. Arthritis & Rheumatology, 70(8), 1319-1330.

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For research use only. Not intended for any clinical use.

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