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IL1RN Matched Antibody Pair (630) (APMAB-630LY)

This antibody pair set can be used for detecting and quantifying protein level of human IL1RN.
See all IL1RN antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IL1RN polyclonal antibody, 100 ug
Detection Antibody
Anti-IL1RN Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
Alternative Names
Interleukin 1 Receptor Antagonist
Entrez Gene ID
3557
UniProt ID
P18510

Attur, M. G., Petrilli, C. M., Adhikari, S., Iturrate, E., Li, X., Tuminello, S., ... & Abramson, S. B. (2023). Interleukin-1 receptor antagonist gene (IL1RN) variants modulate the cytokine release syndrome and mortality of SARS-CoV-2. medRxiv, 2023-01.

Rokni, M., Sarhadi, M., Heidari Nia, M., Mohamed Khosroshahi, L., Asghari, S., Sargazi, S., ... & Saravani, R. (2022). Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population. Cell Biology International, 46(7), 1109-1127.

Wang, Q., Huang, X., Zhou, S., Ding, Y., Wang, H., Jiang, W., & Xu, M. (2022). IL1RN and PRRX1 as a prognostic biomarker correlated with immune infiltrates in colorectal cancer: evidence from bioinformatic analysis. International Journal of Genomics, 2022.

Maculewicz, E., Antkowiak, B., Antkowiak, O., Borecka, A., Mastalerz, A., Leońska-Duniec, A., ... & Cięszczyk, P. (2022). The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters. BMC genomics, 23(1), 1-12.

Pardeo, M., Rossi, M. N., Pires Marafon, D., Sacco, E., Bracaglia, C., Passarelli, C., ... & De Benedetti, F. (2021). Early treatment and IL1RN single‐nucleotide polymorphisms affect response to anakinra in systemic juvenile idiopathic arthritis. Arthritis & Rheumatology, 73(6), 1053-1061.

Li, J., Zeng, X., & Wang, W. (2021). miR‑122‑5p downregulation attenuates lipopolysaccharide‑induced acute lung injury by targeting IL1RN. Experimental and therapeutic medicine, 22(5), 1-10.

Attur, M., Zhou, H., Samuels, J., Krasnokutsky, S., Yau, M., Scher, J. U., ... & Abramson, S. B. (2020). Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease. Annals of the Rheumatic Diseases, 79(3), 400-407.

Kuemmerle-Deschner, J. B., Welzel, T., Hoertnagel, K., Tsiflikas, I., Hospach, A., Liu, X., ... & Weber, A. N. (2020). New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation. Rheumatology, 59(11), 3259-3263.

Teresa, F., Serra, N., Capra, G., Mascarella, C., Gagliardi, C., Di Carlo, P., ... & Giammanco, A. (2019). Helicobacter pylori and epstein–barr virus infection in gastric diseases: correlation with IL-10 and IL1RN polymorphism. Journal of oncology, 2019.

Arthur, V. L., Shuldiner, E., Remmers, E. F., Hinks, A., Grom, A. A., Foell, D., ... & Davidson, J. (2018). IL1RN variation influences both disease susceptibility and response to recombinant human interleukin‐1 receptor antagonist therapy in systemic juvenile idiopathic arthritis. Arthritis & Rheumatology, 70(8), 1319-1330.

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For research use only. Not intended for any clinical use.

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