IL2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Full Name
Interleukin 2
Alternative Names
Interleukin 2
Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Cellular Location
Secreted
Involvement in disease
A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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Anti-IL2 antibodies
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CompareTarget: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A532
Application*: ICC, IHC, IP, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: KT7
Application*: ELISA
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1392
Application*: WB, IC, P, C, E
Target: IL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I1685
Application*: WB, IP
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5334
Application*: N, IS, IC, MC
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: N7.48A
Application*: F, IH, IF, P
Target: IL2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG104
Application*: IP, N, WB
Target: Il2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYJT-1393
Application*: WB, IC, P, C, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT769
Application*: WB, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3085
Application*: WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A531
Application*: ICC, IHC, IP, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Chicken
Clone: A530
Application*: ICC, IHC, IP, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A529
Application*: Sandwich ELISA, WB, IHC
Target: IL2
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: A528
Application*: Sandwich ELISA, Western Blot
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A527
Application*: Sandwich ELISA, Western Blot
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A526
Application*: WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: A525
Application*: ICC, IHC, IP, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A524
Application*: Dot blot, ELISA, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: A523
Application*: ELISA, IHC, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: A522
Application*: ICC, IHC, IP, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF232
Application*: ELISA, WB, IHC
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0176
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0175
Application*: FC, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0174
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0173
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0172
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0171
Application*: E
Target: IL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7A5
Application*: WB, IP
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C8
Application*: WB, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C1
Application*: E, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1549
Application*: ED
Target: IL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1514
Application*: IP, C, N, F
Target: IL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1513
Application*: F, IH, IP, C, MC
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I1496
Application*: FN, N
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Pig
Clone: CBYY-I1470
Application*: E
Target: IL2
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I1290
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I1275
Application*: F
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1179
Application*: N
Target: IL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I1178
Application*: E, F, IH, IP, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Pig
Clone: CBYY-I1082
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Pig
Clone: CBYY-I1081
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-I1070
Application*: E, IP
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I1061
Application*: E, IH
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1059
Application*: E, F, IH, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BG5
Application*: E, WB, FN, F, BL
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B025M
Application*: E, FN
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: AT2D5
Application*: F, E, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0839
Application*: F
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: A150D 8H10
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Pig
Clone: A150D 3F1
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9F9
Application*: EC
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Pig
Clone: CBYY-I0794
Application*: E, F, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D5
Application*: E, WB, P, IF, F
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8C2
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0759
Application*: F
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 7H11AB7
Application*: IP, WB, F, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F11
Application*: E, IF
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6B1
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 627CT14.8.1
Application*: E, WB
Target: IL2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0665
Application*: E, IP, WB
Target: IL2
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBYY-I0662
Application*: E, N
Target: IL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0645
Application*: E, WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0639
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5A8
Application*: E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYY-I0628
Application*: WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0621
Application*: IC, EC, IF
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken
Clone: 4F12
Application*: E, FN
Target: IL2
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: I2-C7
Application*: FN, E
Target: IL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: S4B6-1
Application*: BL, WB, P, IP, F, E, N
Target: IL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: S4B6
Application*: BL, E, F, IH, WB, N, FN
Target: IL2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0432
Application*: F
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0360
Application*: E, ES, F
Target: IL2
Host: Mouse
Antibody Isotype: IgG1, IgG2b
Specificity: Human
Clone: CBYY-I0356
Application*: E, ES
Target: IL2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: MQ1-17H12
Application*: E, ES, IS, IH, IP, MC
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0284
Application*: E
Target: IL2
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: JES6-5H4
Application*: ED, EC, F, C, IP, IS, FN
Target: IL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: JES6-1A12
Application*: WB, IP, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I0172
Application*: WB, P
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0171
Application*: WB, F, E
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 297C16G2
Application*: E, C, P
Target: IL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 297C16F11
Application*: DB, IH, I, N
Target: IL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2000000
Application*: E
Target: IL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 1A12
Application*: ES, E, WB, BL, N
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYY-I0170
Application*: WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Pig
Clone: CBYY-I0169
Application*: WB
Target: IL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Pig
Clone: CBYY-I0168
Application*: E, F, WB, MC, IS
Target: IL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: H2E4
Application*: WB, P, IF
Target: IL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: S4B6-1
Application*: N
Target: IL2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: JES6-1A12
Application*: N
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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