Human Recombinant IL2, GMP grade protein (V2LY-0526-LY4825)

Name: Human Recombinant IL2, GMP grade protein
SKU: V2LY-0526-LY4825
Rating: 5 (1 reviews)

See all IL2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant IL2, GMP grade protein consist of Amino Acid: 21-153 and predicts a molecular mass of 15.5 kDa.

Molecule Mass

15.5 kDa

Verified

HPLC

Sequence

Amino Acid: 21-153

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

<5 EU/mg of the protein.

Format

Liquid

Preservative

None

Storage

Samples are stable for up to thirty-six months from date of receipt at -20°C to -80°C.Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 2

Alternative Names

Interleukin 2

Function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Cellular Location

Secreted

Involvement in disease

A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Liu, Y., Zhou, N., Zhou, L., Wang, J., Zhou, Y., Zhang, T., ... & Huang, B. (2021). IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor. Nature immunology, 22(3), 358-369.

Lopes, J. E., Fisher, J. L., Flick, H. L., Wang, C., Sun, L., Ernstoff, M. S., ... & Losey, H. C. (2020). ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. Journal for immunotherapy of cancer, 8(1).

Damoiseaux, J. (2020). The IL-2–IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor. Clinical Immunology, 218, 108515.

Papillion, A., Powell, M. D., Chisolm, D. A., Bachus, H., Fuller, M. J., Weinmann, A. S., ... & Ballesteros-Tato, A. (2019). Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells. Science immunology, 4(39), eaaw7636.

Forsberg, E. M., Lindberg, M. F., Jespersen, H., Alsén, S., Bagge, R. O., Donia, M., ... & Nilsson, J. A. (2019). HER2 CAR-T cells eradicate uveal melanoma and T-cell therapy–resistant human melanoma in IL2 transgenic NOD/SCID IL2 receptor knockout mice. Cancer Research, 79(5), 899-904.

Mortara, L., Balza, E., Bruno, A., Poggi, A., Orecchia, P., & Carnemolla, B. (2018). Anti-cancer therapies employing IL-2 cytokine tumor targeting: contribution of innate, adaptive and immunosuppressive cells in the anti-tumor efficacy. Frontiers in Immunology, 9, 2905.

Abbas, A. K., Trotta, E., R. Simeonov, D., Marson, A., & Bluestone, J. A. (2018). Revisiting IL-2: Biology and therapeutic prospects. Science immunology, 3(25), eaat1482.

Sockolosky, J. T., Trotta, E., Parisi, G., Picton, L., Su, L. L., Le, A. C., ... & Garcia, K. C. (2018). Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science, 359(6379), 1037-1042.

Fan, M. Y., Low, J. S., Tanimine, N., Finn, K. K., Priyadharshini, B., Germana, S. K., ... & Turka, L. A. (2018). Differential roles of IL-2 signaling in developing versus mature Tregs. Cell reports, 25(5), 1204-1213.

DiToro, D., Winstead, C. J., Pham, D., Witte, S., Andargachew, R., Singer, J. R., ... & Weaver, C. T. (2018). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science, 361(6407), eaao2933.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant IL2, GMP grade protein?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL2 (147 Cys/Ser) protein (CAT#: V2LY-0526-LY1277)

Human Recombinant IL2 protein, His Tag (CAT#: V2LY-0526-LY4824)

Human Recombinant IL2 protein (CAT#: V2LY-0526-LY4826)

Human Recombinant IL2 protein-1 (CAT#: V2LY-0526-LY4827)

Mouse Recombinant IL2 protein (CAT#: V2LY-0526-LY8512)

Mouse Recombinant IL2 protein, hFc Tag (CAT#: V2LY-0526-LY8513)

Rat Recombinant IL2 protein (CAT#: V2LY-0526-LY9454)

Related Products

Rat Anti-IL2 Recombinant Antibody (CBYY-I1178) (CAT#: CBMAB-I2346-YY)

Mouse Anti-IL2 Monoclonal Antibody (CBFYR0171) (CAT#: CBMAB-R0171-FY)

Mouse Anti-IL2 Recombinant Antibody (3C8) (CAT#: CBMAB-A4389-LY)

Mouse Anti-IL2 Recombinant Antibody (CBYY-I1496) (CAT#: CBMAB-I2666-YY)

Mouse Anti-IL2 Recombinant Antibody (8C2) (CAT#: CBMAB-I1752-YY)

Mouse Anti-IL2 Recombinant Antibody (5A8) (CAT#: CBMAB-I1414-YY)

Human Recombinant IL2 protein-1 (CAT#: V2LY-0526-LY4827)

Mouse Anti-IL2 (AA 14-0) Recombinant Antibody (CBYY-I0169) (CAT#: CBMAB-I0476-YY)

Canine Recombinant IL2 (147 Cys/Ser) protein (CAT#: V2LY-0526-LY1277)

Mouse Anti-IL2 Recombinant Antibody (CBYY-I0794) (CAT#: CBMAB-I1771-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry