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Rat Anti-IL2 Recombinant Antibody (JES6-5H4) (CBMAB-I0780-YY)

This product is Rat antibody that recognizes IL2. The antibody JES6-5H4 can be used for immunoassay techniques such as: ELISA(Det), ELISA(Cap), FC, IHC-Fr, IP, ICFC, FuncS
See all IL2 antibodies
Published Data
Fig.1 TTP deficiency promotes CD8⁺ T-cell activation.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
JES6-5H4
Antibody Isotype
IgG2b, κ
Application
ELISA(Det), ELISA(Cap), FC, IHC-Fr, IP, ICFC, FuncS

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 2
Introduction
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Entrez Gene ID
16183
UniProt ID
P04351
Alternative Names
Interleukin 2
Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Cellular Location
Secreted
Involvement in disease
A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Liu, Y., Zhou, N., Zhou, L., Wang, J., Zhou, Y., Zhang, T., ... & Huang, B. (2021). IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor. Nature immunology, 22(3), 358-369.

Lopes, J. E., Fisher, J. L., Flick, H. L., Wang, C., Sun, L., Ernstoff, M. S., ... & Losey, H. C. (2020). ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. Journal for immunotherapy of cancer, 8(1).

Damoiseaux, J. (2020). The IL-2–IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor. Clinical Immunology, 218, 108515.

Papillion, A., Powell, M. D., Chisolm, D. A., Bachus, H., Fuller, M. J., Weinmann, A. S., ... & Ballesteros-Tato, A. (2019). Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells. Science immunology, 4(39), eaaw7636.

Forsberg, E. M., Lindberg, M. F., Jespersen, H., Alsén, S., Bagge, R. O., Donia, M., ... & Nilsson, J. A. (2019). HER2 CAR-T cells eradicate uveal melanoma and T-cell therapy–resistant human melanoma in IL2 transgenic NOD/SCID IL2 receptor knockout mice. Cancer Research, 79(5), 899-904.

Mortara, L., Balza, E., Bruno, A., Poggi, A., Orecchia, P., & Carnemolla, B. (2018). Anti-cancer therapies employing IL-2 cytokine tumor targeting: contribution of innate, adaptive and immunosuppressive cells in the anti-tumor efficacy. Frontiers in Immunology, 9, 2905.

Abbas, A. K., Trotta, E., R. Simeonov, D., Marson, A., & Bluestone, J. A. (2018). Revisiting IL-2: Biology and therapeutic prospects. Science immunology, 3(25), eaat1482.

Sockolosky, J. T., Trotta, E., Parisi, G., Picton, L., Su, L. L., Le, A. C., ... & Garcia, K. C. (2018). Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science, 359(6379), 1037-1042.

Fan, M. Y., Low, J. S., Tanimine, N., Finn, K. K., Priyadharshini, B., Germana, S. K., ... & Turka, L. A. (2018). Differential roles of IL-2 signaling in developing versus mature Tregs. Cell reports, 25(5), 1204-1213.

DiToro, D., Winstead, C. J., Pham, D., Witte, S., Andargachew, R., Singer, J. R., ... & Weaver, C. T. (2018). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science, 361(6407), eaao2933.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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