IL25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants.
Full Name
Interleukin 25
Function
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Biological Process
Eosinophil differentiationIEA:Ensembl
Inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Response to fungusIEA:Ensembl
Response to nematodeIEA:Ensembl
Inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Response to fungusIEA:Ensembl
Response to nematodeIEA:Ensembl
Cellular Location
Secreted
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Anti-IL25 antibodies
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CompareTarget: IL25
Sensitivity: 0.011 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IL25
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 17-169
Tag: hFc Tag
Target: IL25
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 17-169
Tag: His Tag
Target: IL25
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 33-177
Tag: hFc Tag
Target: IL25
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 17-169
Tag: hFc Tag
Target: IL25
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Human
Clone: CBYY-I1126
Application*: WB
Target: IL25
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1075
Application*: WB
Target: IL25
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8B1
Application*: F, WB
Target: IL25
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0787
Application*: N
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 7H5
Application*: F
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 6D502
Application*: E, WB
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 68C1039.2
Application*: WB, P
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D10
Application*: E
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse, Human, Mouse
Clone: 4H194
Application*: E, WB
Target: IL25
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I0448
Application*: WB, IF, F
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0340
Application*: WB, F, MC
Target: IL25
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0192
Application*: WB
Target: IL25
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 207702
Application*: IS, MC, E
Target: IL25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 182203
Application*: WB, IS, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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