Sign in or Register   Sign in or Register
  |  

Mouse Anti-IL25 Recombinant Antibody (CBYY-I1126) (CBMAB-I2294-YY)

This product is Mouse antibody that recognizes IL25. The antibody CBYY-I1126 can be used for immunoassay techniques such as: WB
See all IL25 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
CBYY-I1126
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.4 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 25
Introduction
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human64806
Mouse140806
UniProt ID
HumanQ9H293
MouseQ8VHH8
Alternative Names
Interleukin 25
Function
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Biological Process
Eosinophil differentiationIEA:Ensembl
Inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Response to fungusIEA:Ensembl
Response to nematodeIEA:Ensembl
Cellular Location
Secreted

Chen, J., Wang, Y., Shen, L., Xiu, Y., & Wang, B. (2023). Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?. Cytokine & Growth Factor Reviews, 69, 43-50.

Jou, E., Rodriguez-Rodriguez, N., Ferreira, A. C. F., Jolin, H. E., Clark, P. A., Sawmynaden, K., ... & McKenzie, A. N. (2022). An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis. Science immunology, 7(72), eabn0175.

Zhang, K., Feng, Y., Liang, Y., Wu, W., Chang, C., Chen, D., ... & Zhen, G. (2021). Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2–high asthma. JCI insight, 6(11).

Borowczyk, J., Shutova, M., Brembilla, N. C., & Boehncke, W. H. (2021). IL-25 (IL-17E) in epithelial immunology and pathophysiology. Journal of Allergy and Clinical Immunology, 148(1), 40-52.

Deng, C., Peng, N., Tang, Y., Yu, N., Wang, C., Cai, X., ... & Lu, L. (2021). Roles of IL-25 in type 2 inflammation and autoimmune pathogenesis. Frontiers in Immunology, 12, 691559.

Ualiyeva, S., Lemire, E., Aviles, E. C., Wong, C., Boyd, A. A., Lai, J., ... & Bankova, L. G. (2021). Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. Science immunology, 6(66), eabj0474.

Leyva-Castillo, J. M., Galand, C., Mashiko, S., Bissonnette, R., McGurk, A., Ziegler, S. F., ... & Geha, R. S. (2020). ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. Journal of Allergy and Clinical Immunology, 145(6), 1606-1614.

Hiraishi, Y., Yamaguchi, S., Yoshizaki, T., Nambu, A., Shimura, E., Takamori, A., ... & Nakae, S. (2018). IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. Scientific reports, 8(1), 18052.

Bornstein, C., Nevo, S., Giladi, A., Kadouri, N., Pouzolles, M., Gerbe, F., ... & Amit, I. (2018). Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells. Nature, 559(7715), 622-626.

Bankova, L. G., Dwyer, D. F., Yoshimoto, E., Ualiyeva, S., McGinty, J. W., Raff, H., ... & Barrett, N. A. (2018). The cysteinyl leukotriene 3 receptor regulates expansion of IL-25–producing airway brush cells leading to type 2 inflammation. Science immunology, 3(28), eaat9453.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IL25 Recombinant Antibody (CBYY-I1126)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare