ITGB8

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Full Name

integrin beta 8

Function

Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072).
It recognizes the sequence R-G-D in its ligands (PubMed:1918072).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).

Biological Process

Cartilage developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Ganglioside metabolic processIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Langerhans cell differentiationIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Placenta blood vessel developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:ComplexPortal
Response to virusIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
VasculogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 43-684
Helical: 685-704
Cytoplasmic: 705-769