Mouse Anti-ITGB8 Recombinant Antibody (2B4) (CBMAB-I0110-YY)

Name: Mouse Anti-ITGB8 Recombinant Antibody (2B4)
SKU: CBMAB-I0110-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B4

Application

ELISA, IP, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

integrin beta 8

Introduction

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Entrez Gene ID

3696

UniProt ID

P26012

Alternative Names

Integrin Subunit Beta 8

Function

Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072).
It recognizes the sequence R-G-D in its ligands (PubMed:1918072).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).

Biological Process

Cartilage developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Ganglioside metabolic processIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Langerhans cell differentiationIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Placenta blood vessel developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:ComplexPortal
Response to virusIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
VasculogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 43-684
Helical: 685-704
Cytoplasmic: 705-769

Jin, Z., Jiao, Z., Song, L., Zhang, Y., Zhang, M., & Zhao, Y. (2023). Prognostic implication of ITGB8 and its relationship with immune response.

Lin, X., Zhuang, S., Chen, X., Du, J., Zhong, L., Ding, J., ... & Ye, F. (2022). lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. Molecular Therapy, 30(2), 688-702.

Bu, L. G., Sun, Y., Li, T. Y., Kong, L. L., Yu, H. N., Li, S. J., ... & Ni, H. (2022). Peri-implantation expression and regulation of ITGB8 in goat uterus. Theriogenology, 180, 130-136.

Li, J., Zhu, T., Weng, Y., Cheng, F., Sun, Q., Yang, K., ... & Ma, H. (2022). Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR‐139‐5p/ITGB8. Thoracic cancer, 13(9), 1381-1390.

Li, N., & Zhu, D. (2021). Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis. Cell Cycle, 1-13.

Wei, C. M., Zhao, X. F., Qiu, H. B., Ming, Z., Liu, K., & Yan, J. (2020). The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells. Neoplasma, 67(4), 802-812.

Zhang, H. Y., Zhang, B. W., Zhang, Z. B., & Deng, Q. J. (2020). Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. European Review for Medical & Pharmacological Sciences, 24(5).

Wu, P., Wang, Y., Wu, Y., Jia, Z., Song, Y., & Liang, N. (2019). Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PeerJ, 7, e8299.

Li, G., Yang, H., Han, K., Zhu, D., Lun, P., & Zhao, Y. (2018). A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma. Biochemical and biophysical research communications, 498(1), 254-261.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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