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Rabbit Anti-ITGB8 Recombinant Antibody (D1V7M) (CBMAB-CP1237-LY)

The product is antibody recognizes ITGB8. The antibody D1V7M immunoassay techniques such as: WB.
See all ITGB8 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
D1V7M
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant mouse integrin β8 protein.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
integrin beta 8
Introduction
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Entrez Gene ID
320910
UniProt ID
Q0VBD0
Alternative Names
4832412O06Rik
Function
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072).
It recognizes the sequence R-G-D in its ligands (PubMed:1918072).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).
Biological Process
Cartilage developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Ganglioside metabolic processIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Langerhans cell differentiationIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Placenta blood vessel developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:ComplexPortal
Response to virusIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
VasculogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 43-684
Helical: 685-704
Cytoplasmic: 705-769

Jin, Z., Jiao, Z., Song, L., Zhang, Y., Zhang, M., & Zhao, Y. (2023). Prognostic implication of ITGB8 and its relationship with immune response.

Lin, X., Zhuang, S., Chen, X., Du, J., Zhong, L., Ding, J., ... & Ye, F. (2022). lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. Molecular Therapy, 30(2), 688-702.

Bu, L. G., Sun, Y., Li, T. Y., Kong, L. L., Yu, H. N., Li, S. J., ... & Ni, H. (2022). Peri-implantation expression and regulation of ITGB8 in goat uterus. Theriogenology, 180, 130-136.

Li, J., Zhu, T., Weng, Y., Cheng, F., Sun, Q., Yang, K., ... & Ma, H. (2022). Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR‐139‐5p/ITGB8. Thoracic cancer, 13(9), 1381-1390.

Li, N., & Zhu, D. (2021). Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis. Cell Cycle, 1-13.

Wei, C. M., Zhao, X. F., Qiu, H. B., Ming, Z., Liu, K., & Yan, J. (2020). The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells. Neoplasma, 67(4), 802-812.

Zhang, H. Y., Zhang, B. W., Zhang, Z. B., & Deng, Q. J. (2020). Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. European Review for Medical & Pharmacological Sciences, 24(5).

Wu, P., Wang, Y., Wu, Y., Jia, Z., Song, Y., & Liang, N. (2019). Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PeerJ, 7, e8299.

Li, G., Yang, H., Han, K., Zhu, D., Lun, P., & Zhao, Y. (2018). A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma. Biochemical and biophysical research communications, 498(1), 254-261.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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