Human ITGB8 ELISA Kit (V2LY-0626-LY4736)

Name: Human ITGB8 ELISA Kit
SKU: V2LY-0626-LY4736
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.053 ng/mL

Detection Range

0.1-40 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

85.6 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

integrin beta 8

Function

Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072).
It recognizes the sequence R-G-D in its ligands (PubMed:1918072).
Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).

Biological Process

Cartilage developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Ganglioside metabolic processIEA:Ensembl
Hard palate developmentIEA:Ensembl
Immune responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Langerhans cell differentiationIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Placenta blood vessel developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:ComplexPortal
Response to virusIEA:Ensembl
Transforming growth factor beta receptor signaling pathwayIEA:Ensembl
VasculogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 43-684
Helical: 685-704
Cytoplasmic: 705-769

Jin, Z., Jiao, Z., Song, L., Zhang, Y., Zhang, M., & Zhao, Y. (2023). Prognostic implication of ITGB8 and its relationship with immune response.

Lin, X., Zhuang, S., Chen, X., Du, J., Zhong, L., Ding, J., ... & Ye, F. (2022). lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. Molecular Therapy, 30(2), 688-702.

Bu, L. G., Sun, Y., Li, T. Y., Kong, L. L., Yu, H. N., Li, S. J., ... & Ni, H. (2022). Peri-implantation expression and regulation of ITGB8 in goat uterus. Theriogenology, 180, 130-136.

Li, J., Zhu, T., Weng, Y., Cheng, F., Sun, Q., Yang, K., ... & Ma, H. (2022). Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR‐139‐5p/ITGB8. Thoracic cancer, 13(9), 1381-1390.

Li, N., & Zhu, D. (2021). Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis. Cell Cycle, 1-13.

Wei, C. M., Zhao, X. F., Qiu, H. B., Ming, Z., Liu, K., & Yan, J. (2020). The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells. Neoplasma, 67(4), 802-812.

Zhang, H. Y., Zhang, B. W., Zhang, Z. B., & Deng, Q. J. (2020). Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. European Review for Medical & Pharmacological Sciences, 24(5).

Wu, P., Wang, Y., Wu, Y., Jia, Z., Song, Y., & Liang, N. (2019). Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PeerJ, 7, e8299.

Li, G., Yang, H., Han, K., Zhu, D., Lun, P., & Zhao, Y. (2018). A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma. Biochemical and biophysical research communications, 498(1), 254-261.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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