LILRA3

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).[supplied by OMIM
Full Name
LILRA3
Function
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
N-glycosylation is required for ligand binding.
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Anti-LILRA3 antibodies

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Mouse Anti-LILRA3 Recombinant Antibody (2E9) (CBMAB-A4992-LY)

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Target: LILRA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E9
Application*: WB, E
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Mouse Anti-LILRA3 Recombinant Antibody (CBT2027) (V2LY-0625-LY1050)

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Target: LILRA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2027
Application*: F
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LILRA3 Matched Antibody Pair (692) (APMAB-692LY)

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Target: LILRA3
Specificity: Human
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Mouse Anti-LILRA3 Recombinant Antibody (CBYJL-1670) (CBMAB-L1543-YJ)

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Target: LILRA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1670
Application*: E, EC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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