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LILRA3

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).[supplied by OMIM

Full Name

LILRA3

Function

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

PTM

N-glycosylation is required for ligand binding.

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Anti-LILRA3 antibodies

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Mouse Anti-LILRA3 Recombinant Antibody (2E9) (CBMAB-A4992-LY)

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Target: LILRA3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E9

Application*: WB, E

Mouse Anti-LILRA3 Recombinant Antibody (CBT2027) (V2LY-0625-LY1050)

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Target: LILRA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2027

Application*: F

LILRA3 Matched Antibody Pair (692) (APMAB-692LY)

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Target: LILRA3

Specificity: Human

Mouse Anti-LILRA3 Recombinant Antibody (CBYJL-1670) (CBMAB-L1543-YJ)

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Target: LILRA3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1670

Application*: E, EC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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