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Mouse Anti-LILRA3 Recombinant Antibody (CBYJL-1670) (CBMAB-L1543-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leukocyte Immunoglobulin Like Receptor A3 (LILRA3). The antibody can be used for immunoassay techniques, such as ELISA, ELISA(Cap).
See all LILRA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1670
Antibody Isotype
IgG2a
Application
ELISA, ELISA(Cap)

Basic Information

Immunogen
Recombinant Human ILT6/LILRA3 Protein.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LILRA3
Introduction
LILRA3 is a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. LILRA3 lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been observed. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. Diseases associated with LILRA3 include Lethal Midline Granuloma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. Gene Ontology (GO) annotations related to this gene include antigen binding. It acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Entrez Gene ID
11026
UniProt ID
Q8N6C8
Alternative Names
HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
Function
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
N-glycosylation is required for ligand binding.

Liu, H., Li, C., Shi, H., Guo, Y., Tang, Y., Chen, C., ... & Guo, J. (2022). Soluble LILRA3 is aberrantly expressed in antiphospholipid syndrome (APS) and is a potential marker of thrombotic APS. Rheumatology, 61(12), 4962-4974.

Argyriou, E., Nezos, A., Roussos, P., Venetsanopoulou, A., Voulgarelis, M., Boki, K., ... & Mavragani, C. P. (2021). Leukocyte immunoglobulin-like receptor A3 (LILRA3): a novel marker for lymphoma development among patients with young onset Sjogren’s syndrome. Journal of Clinical Medicine, 10(4), 644.

Kadoba, K., Watanabe, R., Iwasaki, T., Nakajima, T., Kitagori, K., Akizuki, S., ... & Yoshifuji, H. (2021). A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis. Scientific Reports, 11(1), 13667.

Wu, X., Cheng, Q., Jiang, H., Zhou, M., Chen, X., Wu, H., ... & Du, Y. (2021). LILRA3 is related to monocyte-derived dendritic cell maturation and activation. Iranian Journal of Basic Medical Sciences, 24(2), 196.

Wang, H., Wang, Y., Tang, Y., Ye, H., Zhang, X., Zhou, G., ... & Wang, Q. (2019). Frequencies of the LILRA3 6.7-kb deletion are highly differentiated among Han Chinese subpopulations and involved in ankylosing spondylitis predisposition. Frontiers in Genetics, 10, 869.

Du, Y., Sun, F., Zhou, M., Wu, X., Sun, W., Jiang, Y., ... & Xue, J. (2019). The expression and clinical significance of different forms of LILRA3 in systemic lupus erythematosus. Clinical Rheumatology, 38, 3099-3107.

Argyriou, E., Roussos, P., Nezos, A., Venetsanopoulou, A., Boki, K. A., Tzioufas, A., ... & Mavragani, C. (2019). Thu0204 Association of Lilra3 Gene with Lymphomagenesis Risk in Young Ss Patients.

Terao, C., Yoshifuji, H., Matsumura, T., Naruse, T. K., Ishii, T., Nakaoka, Y., ... & Matsuda, F. (2018). Genetic determinants and an epistasis of LILRA3 and HLA-B* 52 in Takayasu arteritis. Proceedings of the National Academy of Sciences, 115(51), 13045-13050.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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