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Mouse Anti-LILRA3 Recombinant Antibody (2E9) (CBMAB-A4992-LY)

The product is antibody recognizes LILRA3. The antibody 2E9 immunoassay techniques such as: WB, ELISA.
See all LILRA3 antibodies
Published Data
Fig.1 Induction of LILRA3 in PBMCS by ssRNA40 on the protein level.
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Fig.2 Pastoris using anti-LILRA3 mAb showed a substantial reduction in molecular mass of both eukaryotic cell-produced recombinant proteins following deglycosylation.
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Fig.3 Western blot analysis of 2 independent PBMC lysates using anti-LILRA3 mAb.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
LILRA3 (AAH28208.1, 1 a.a. ~ 439 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LILRA3
Introduction
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).[supplied by OMIM
Entrez Gene ID
11026
UniProt ID
Q8N6C8
Alternative Names
CD85E; HM31; HM43; ILT6; LIR-4; LIR4; e3
Function
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
N-glycosylation is required for ligand binding.

Liu, H., Li, C., Shi, H., Guo, Y., Tang, Y., Chen, C., ... & Guo, J. (2022). Soluble LILRA3 is aberrantly expressed in antiphospholipid syndrome (APS) and is a potential marker of thrombotic APS. Rheumatology, 61(12), 4962-4974.

Argyriou, E., Nezos, A., Roussos, P., Venetsanopoulou, A., Voulgarelis, M., Boki, K., ... & Mavragani, C. P. (2021). Leukocyte immunoglobulin-like receptor A3 (LILRA3): a novel marker for lymphoma development among patients with young onset Sjogren’s syndrome. Journal of Clinical Medicine, 10(4), 644.

Kadoba, K., Watanabe, R., Iwasaki, T., Nakajima, T., Kitagori, K., Akizuki, S., ... & Yoshifuji, H. (2021). A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis. Scientific Reports, 11(1), 13667.

Wu, X., Cheng, Q., Jiang, H., Zhou, M., Chen, X., Wu, H., ... & Du, Y. (2021). LILRA3 is related to monocyte-derived dendritic cell maturation and activation. Iranian Journal of Basic Medical Sciences, 24(2), 196.

Wang, H., Wang, Y., Tang, Y., Ye, H., Zhang, X., Zhou, G., ... & Wang, Q. (2019). Frequencies of the LILRA3 6.7-kb deletion are highly differentiated among Han Chinese subpopulations and involved in ankylosing spondylitis predisposition. Frontiers in Genetics, 10, 869.

Du, Y., Sun, F., Zhou, M., Wu, X., Sun, W., Jiang, Y., ... & Xue, J. (2019). The expression and clinical significance of different forms of LILRA3 in systemic lupus erythematosus. Clinical Rheumatology, 38, 3099-3107.

Argyriou, E., Roussos, P., Nezos, A., Venetsanopoulou, A., Boki, K. A., Tzioufas, A., ... & Mavragani, C. (2019). Thu0204 Association of Lilra3 Gene with Lymphomagenesis Risk in Young Ss Patients.

Terao, C., Yoshifuji, H., Matsumura, T., Naruse, T. K., Ishii, T., Nakaoka, Y., ... & Matsuda, F. (2018). Genetic determinants and an epistasis of LILRA3 and HLA-B* 52 in Takayasu arteritis. Proceedings of the National Academy of Sciences, 115(51), 13045-13050.

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For research use only. Not intended for any clinical use.

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