Human Recombinant LILRA3 protein, His Tag (V2LY-0526-LY5309)

Name: Human Recombinant LILRA3 protein, His Tag
SKU: V2LY-0526-LY5309
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LILRA3 protein, His Tag consist of Amino Acid: 1-439 and predicts a molecular mass of 46.5 kDa.

Molecule Mass

46.5 kDa

Verified

HPLC

Sequence

Amino Acid: 1-439

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥85% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LILRA3

Function

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

PTM

N-glycosylation is required for ligand binding.

Liu, H., Li, C., Shi, H., Guo, Y., Tang, Y., Chen, C., ... & Guo, J. (2022). Soluble LILRA3 is aberrantly expressed in antiphospholipid syndrome (APS) and is a potential marker of thrombotic APS. Rheumatology, 61(12), 4962-4974.

Argyriou, E., Nezos, A., Roussos, P., Venetsanopoulou, A., Voulgarelis, M., Boki, K., ... & Mavragani, C. P. (2021). Leukocyte immunoglobulin-like receptor A3 (LILRA3): a novel marker for lymphoma development among patients with young onset Sjogren’s syndrome. Journal of Clinical Medicine, 10(4), 644.

Kadoba, K., Watanabe, R., Iwasaki, T., Nakajima, T., Kitagori, K., Akizuki, S., ... & Yoshifuji, H. (2021). A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis. Scientific Reports, 11(1), 13667.

Wu, X., Cheng, Q., Jiang, H., Zhou, M., Chen, X., Wu, H., ... & Du, Y. (2021). LILRA3 is related to monocyte-derived dendritic cell maturation and activation. Iranian Journal of Basic Medical Sciences, 24(2), 196.

Wang, H., Wang, Y., Tang, Y., Ye, H., Zhang, X., Zhou, G., ... & Wang, Q. (2019). Frequencies of the LILRA3 6.7-kb deletion are highly differentiated among Han Chinese subpopulations and involved in ankylosing spondylitis predisposition. Frontiers in Genetics, 10, 869.

Du, Y., Sun, F., Zhou, M., Wu, X., Sun, W., Jiang, Y., ... & Xue, J. (2019). The expression and clinical significance of different forms of LILRA3 in systemic lupus erythematosus. Clinical Rheumatology, 38, 3099-3107.

Argyriou, E., Roussos, P., Nezos, A., Venetsanopoulou, A., Boki, K. A., Tzioufas, A., ... & Mavragani, C. (2019). Thu0204 Association of Lilra3 Gene with Lymphomagenesis Risk in Young Ss Patients.

Terao, C., Yoshifuji, H., Matsumura, T., Naruse, T. K., Ishii, T., Nakaoka, Y., ... & Matsuda, F. (2018). Genetic determinants and an epistasis of LILRA3 and HLA-B* 52 in Takayasu arteritis. Proceedings of the National Academy of Sciences, 115(51), 13045-13050.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LILRA3 protein, hFc Tag (CAT#: V2LY-0526-LY5307)

Human Recombinant LILRA3 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY5308)

LILRA3 Matched Antibody Pair (692) (CAT#: APMAB-692LY)

Antibody Pairs

LILRA3 Matched Antibody Pair (692) (CAT#: APMAB-692LY)

Related Products

Human Recombinant LILRA3 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY5308)

Mouse Anti-LILRA3 Recombinant Antibody (CBYJL-1670) (CAT#: CBMAB-L1543-YJ)

LILRA3 Matched Antibody Pair (692) (CAT#: APMAB-692LY)

Mouse Anti-LILRA3 Recombinant Antibody (2E9) (CAT#: CBMAB-A4992-LY)

Human Recombinant LILRA3 protein, hFc Tag (CAT#: V2LY-0526-LY5307)

Mouse Anti-LILRA3 Recombinant Antibody (CBT2027) (CAT#: V2LY-0625-LY1050)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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