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LILRB3

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
leukocyte immunoglobulin like receptor B3
Function
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-443
Helical: 444-464
Cytoplasmic: 465-631
PTM
Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.
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Anti-LILRB3 antibodies

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Mouse Anti-LILRB3 Recombinant Antibody (222821) (CBMAB-I0132-YY)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 222821
Application*: WB, F, MC, E
Datasheet SDS

Human Anti-LILRB3 Recombinant Antibody (CBXC-0744) (CBMAB-C1858-CQ)

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Target: LILRB3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0744
Application*: F
Datasheet SDS

Rat Anti-LILRB3 Recombinant Antibody (326414) (CBMAB-P0466-YC)

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Target: LILRB3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 326414
Application*: F
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYY-I0604) (CBMAB-I1344-YY)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0604
Application*: F, IH, C
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYY-I0342) (CBMAB-I0886-YY)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0342
Application*: WB, F, P
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1694) (CBMAB-L1573-YJ)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-1694
Application*: WB
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1693) (CBMAB-L1572-YJ)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-1693
Application*: F, WB
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1692) (CBMAB-L1571-YJ)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1692
Application*: E
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1691) (CBMAB-L1570-YJ)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1691
Application*: E, EC
Datasheet SDS

Rabbit Anti-LILRB3 Recombinant Antibody (CBYJL-1690) (CBMAB-L1568-YJ)

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Target: LILRB3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1690
Application*: E
Datasheet SDS

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1689) (CBMAB-L1567-YJ)

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Target: LILRB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1689
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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