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LILRB3

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

leukocyte immunoglobulin like receptor B3

Function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 24-443
Helical: 444-464
Cytoplasmic: 465-631

PTM

Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.

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Anti-LILRB3 antibodies

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Mouse Anti-LILRB3 Recombinant Antibody (222821) (CBMAB-I0132-YY)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 222821

Application*: WB, F, MC, E

Human Anti-LILRB3 Recombinant Antibody (CBXC-0744) (CBMAB-C1858-CQ)

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Target: LILRB3

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0744

Application*: F

Rat Anti-LILRB3 Recombinant Antibody (326414) (CBMAB-P0466-YC)

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Target: LILRB3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 326414

Application*: F

Mouse Recombinant LILRB3 protein, His Tag (V2LY-0526-LY8558)

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Target: LILRB3

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-640

Tag: His Tag

Human Recombinant LILRB3 protein, ECD, Biotin Conjugated, His Tag (V2LY-0526-LY4989)

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Target: LILRB3

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-443

Tag: His Tag

Human Recombinant LILRB3 protein, ECD, His Tag (V2LY-0526-LY4988)

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Target: LILRB3

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-443

Tag: His Tag

Human Recombinant LILRB3 protein, ECD, hFc Tag (V2LY-0526-LY4987)

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Target: LILRB3

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-443

Tag: hFc Tag

Mouse Anti-LILRB3 Recombinant Antibody (CBYY-I0604) (CBMAB-I1344-YY)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0604

Application*: F, IH, C

Mouse Anti-LILRB3 Recombinant Antibody (CBYY-I0342) (CBMAB-I0886-YY)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0342

Application*: WB, F, P

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1694) (CBMAB-L1573-YJ)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJL-1694

Application*: WB

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1693) (CBMAB-L1572-YJ)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJL-1693

Application*: F, WB

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1692) (CBMAB-L1571-YJ)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1692

Application*: E

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1691) (CBMAB-L1570-YJ)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1691

Application*: E, EC

Rabbit Anti-LILRB3 Recombinant Antibody (CBYJL-1690) (CBMAB-L1568-YJ)

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Target: LILRB3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1690

Application*: E

Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1689) (CBMAB-L1567-YJ)

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Target: LILRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1689

Application*: F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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