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Rat Anti-LILRB3 Recombinant Antibody (326414) (CBMAB-P0466-YC)

Provided herein is a Rat monoclonal antibody against Mouse Leukocyte immunoglobulin like receptor B3. The antibody can be used for immunoassay techniques, such as FC.
See all LILRB3 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
326414
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leukocyte immunoglobulin like receptor B3
Introduction
LILRB3 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response.
UniProt ID
P97484
Alternative Names
CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3; LIR3; PIR-B; PIRB
Function
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-443
Helical: 444-464
Cytoplasmic: 465-631
PTM
Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.

Huang, R., Liu, X., Kim, J., Deng, H., Deng, M., Gui, X., ... & Zhang, C. (2023). LILRB3 supports immunosuppressive activity of myeloid cells and tumor development. Cancer Immunology Research.

Mai, S., Hodges, A., Chen, H. M., Zhang, J., Wang, Y. L., Liu, Y., ... & Pan, P. Y. (2023). LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy. Cancer Research, 83(24), 4047-4062.

Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., ... & Shi, Y. (2023). LilrB3 is a putative cell surface receptor of APOE4. Cell Research, 33(2), 116-130.

Zhuang, Q., Liu, Y., Wang, H., Lin, Z., Sun, L., Liu, Y., ... & Mao, Y. (2023). LILRB3 suppresses immunity in glioma and is associated with poor prognosis. Clinical and Translational Medicine, 13(10).

Bashirova, A. A., Kasprzak, W., O’hUigin, C., & Carrington, M. (2023). Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans. Immunogenetics, 75(3), 263-267.

Wu, G., Xu, Y., Schultz, R. D., Chen, H., Xie, J., Deng, M., ... & Zhang, C. C. (2021). LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis. Nature cancer, 2(11), 1170-1184.

Ayukawa, S., Kamoshita, N., Nakayama, J., Teramoto, R., Pishesha, N., Ohba, K., ... & Maruyama, T. (2021). Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction. Nature Immunology, 22(11), 1391-1402.

Hirayasu, K., Sun, J., Hasegawa, G., Hashikawa, Y., Hosomichi, K., Tajima, A., ... & Hanayama, R. (2021). Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. Journal of Human Genetics, 66(7), 739-748.

Yeboah, M., Papagregoriou, C., Jones, D. C., Chan, H. C., Hu, G., McPartlan, J. S., ... & Roghanian, A. (2020). LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation. JCI insight, 5(18).

Zhao, Y., van Woudenbergh, E., Zhu, J., Heck, A. J., van Kessel, K. P., de Haas, C. J., ... & McCarthy, A. J. (2020). The orphan immune receptor LILRB3 modulates fc receptor–mediated functions of neutrophils. The Journal of Immunology, 204(4), 954-966.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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