Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1691) (CBMAB-L1570-YJ)

Name: Mouse Anti-LILRB3 Recombinant Antibody (CBYJL-1691)
SKU: CBMAB-L1570-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1691

Application

ELISA, ELISA(Cap)

Immunogen

Recombinant Human LILRB3 Protein.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

leukocyte immunoglobulin like receptor B3

Introduction

LILRB3 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. LILRB3 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.Diseases associated with LILRB3 include Takayasu Arteritis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System.

Entrez Gene ID

11025

UniProt ID

O75022

Alternative Names

HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6

Function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 24-443
Helical: 444-464
Cytoplasmic: 465-631

PTM

Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.

Huang, R., Liu, X., Kim, J., Deng, H., Deng, M., Gui, X., ... & Zhang, C. (2023). LILRB3 supports immunosuppressive activity of myeloid cells and tumor development. Cancer Immunology Research.

Mai, S., Hodges, A., Chen, H. M., Zhang, J., Wang, Y. L., Liu, Y., ... & Pan, P. Y. (2023). LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy. Cancer Research, 83(24), 4047-4062.

Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., ... & Shi, Y. (2023). LilrB3 is a putative cell surface receptor of APOE4. Cell Research, 33(2), 116-130.

Zhuang, Q., Liu, Y., Wang, H., Lin, Z., Sun, L., Liu, Y., ... & Mao, Y. (2023). LILRB3 suppresses immunity in glioma and is associated with poor prognosis. Clinical and Translational Medicine, 13(10).

Bashirova, A. A., Kasprzak, W., O’hUigin, C., & Carrington, M. (2023). Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans. Immunogenetics, 75(3), 263-267.

Wu, G., Xu, Y., Schultz, R. D., Chen, H., Xie, J., Deng, M., ... & Zhang, C. C. (2021). LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis. Nature cancer, 2(11), 1170-1184.

Ayukawa, S., Kamoshita, N., Nakayama, J., Teramoto, R., Pishesha, N., Ohba, K., ... & Maruyama, T. (2021). Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction. Nature Immunology, 22(11), 1391-1402.

Hirayasu, K., Sun, J., Hasegawa, G., Hashikawa, Y., Hosomichi, K., Tajima, A., ... & Hanayama, R. (2021). Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. Journal of Human Genetics, 66(7), 739-748.

Yeboah, M., Papagregoriou, C., Jones, D. C., Chan, H. C., Hu, G., McPartlan, J. S., ... & Roghanian, A. (2020). LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation. JCI insight, 5(18).

Zhao, Y., van Woudenbergh, E., Zhu, J., Heck, A. J., van Kessel, K. P., de Haas, C. J., ... & McCarthy, A. J. (2020). The orphan immune receptor LILRB3 modulates fc receptor–mediated functions of neutrophils. The Journal of Immunology, 204(4), 954-966.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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