LIPF

This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. [provided by RefSeq]

lipase, gastric

Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049).
Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091).

Lipid catabolic processIEA:UniProtKB-KW
Malate metabolic processIEA:Ensembl
Triglyceride metabolic process1 PublicationNAS:UniProtKB

Secreted