LSP1

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Full Name

lymphocyte-specific protein 1

Function

May play a role in mediating neutrophil activation and chemotaxis.

Biological Process

Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-7IEA:Ensembl
ChemotaxisIEA:Ensembl
Signal transductionIEA:InterPro

Cellular Location

Cell membrane

PTM

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).

Anti-LSP1 antibodies

Mouse Anti-LSP1 Recombinant Antibody (CBYCL-509) (CBMAB-L0410-YC)

Datasheet

SDS

Target: LSP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYCL-509

Application*: IF, WB

Mouse Anti-LSP1 Recombinant Antibody (CBYCL-510) (CBMAB-L0411-YC)

Datasheet

SDS

Target: LSP1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-510

Application*: WB, IH, E

Mouse Anti-LSP1 Recombinant Antibody (CBYCL-511) (CBMAB-L0412-YC)

Datasheet

SDS

Target: LSP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYCL-511

Application*: E, WB

Rabbit Anti-LSP1 (Phosphorylated S204) Recombinant Antibody (PTM-CBMAB-0215LY)

Datasheet

SDS

Target: LSP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Application*: WB, P, PE

Rabbit Anti-LSP1 (Phosphorylated S252) Recombinant Antibody (PTM-CBMAB-0217LY)

Datasheet

SDS

Target: LSP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Application*: WB, P, PE

Datasheet

SDS

Target: LSP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A943

Application*: IHC, IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)