Human Recombinant LSP1 protein, His Tag (V2LY-0526-LY5393)

Name: Human Recombinant LSP1 protein, His Tag
SKU: V2LY-0526-LY5393
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LSP1 protein, His Tag consist of Amino Acid: 1-339 and predicts a molecular mass of 38.7 kDa.

Molecule Mass

38.7 kDa

Sequence

Amino Acid: 1-339

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

lymphocyte-specific protein 1

Function

May play a role in mediating neutrophil activation and chemotaxis.

Biological Process

Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-7IEA:Ensembl
ChemotaxisIEA:Ensembl
Signal transductionIEA:InterPro

Cellular Location

Cell membrane

PTM

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).

Hilchey, S. P., Palshikar, M. G., Mendelson, E. S., Shen, S., Rasam, S., Emo, J. A., ... & Zand, M. S. (2022). Cyclosporine A modulates LSP1 protein levels in Human B cells to attenuate B cell migration at low O2 Levels. Life, 12(8), 1284.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein–Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Le, N. P. K., do Nascimento, A. F., Schneberger, D., Quach, C. C., Zhang, X., Aulakh, G. K., ... & Singh, B. (2022). Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model. Respiratory Research, 23(1), 1-16.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Chen, J., Xiao, Q., Li, X., Liu, R., Long, X., Liu, Z., ... & Li, Y. (2022). The correlation of leukocyte-specific protein 1 (LSP1) rs3817198 (T> C) polymorphism with breast cancer: A meta-analysis. Medicine, 101(45).

Koral, K., Bhushan, B., Stoops, J., Orr, A., Mars, W., & Michalopoulos, G. (2020). Lymphocyte Specific Protein‐1 suppresses TCPOBOP induced hepatocellular proliferation. The FASEB Journal, 34(S1), 1-1.

Cao, J. Y., Guo, Q., Guan, G. F., Zhu, C., Zou, C. Y., Zhang, L. Y., ... & Li, G. Y. (2020). Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma. Aging (Albany NY), 12(2), 1656.

Kwon, R., Hong, B. K., Lee, K. G., Choi, E., Sabbagh, L., Cho, C. S., ... & Kim, W. U. (2020). Regulation of tumor growth by leukocyte-specific protein 1 in T cells. Journal for Immunotherapy of Cancer, 8(2).

Kulkarni, R., Jiang, S., Birrane, G., & Prasad, A. (2020). Lymphocyte‐specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST‐2)‐mediated intracellular trafficking of HIV‐1 in dendritic cells. FEBS letters, 594(12), 1947-1959.

Smeir, M. (2019). Leukocyte specific protein-1 modulates expression and activity of endothelial nitric oxide synthase (Doctoral dissertation, University of Saskatchewan).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-LSP1 (Phosphorylated S204) Recombinant Antibody (CAT#: PTM-CBMAB-0215LY)

Rabbit Anti-LSP1 (Phosphorylated S252) Recombinant Antibody (CAT#: PTM-CBMAB-0217LY)

Rabbit Anti-LSP1 (Phosphorylated S190) Recombinant Antibody (CAT#: PTM-CBMAB-0945LY)

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Mouse Anti-LSP1 Recombinant Antibody (CBYJL-2091) (CAT#: CBMAB-L2233-YJ)

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Mouse Anti-LSP1 Recombinant Antibody (TPD153) (CAT#: CBMAB-L2238-YJ)

Mouse Anti-LSP1 Recombinant Antibody (CBYCL-509) (CAT#: CBMAB-L0410-YC)

Mouse Anti-LSP1 Recombinant Antibody (CBYCL-510) (CAT#: CBMAB-L0411-YC)

Mouse Anti-LSP1 Recombinant Antibody (5E3) (CAT#: CBMAB-L2234-YJ)

Mouse Anti-LSP1 Recombinant Antibody (CBYJL-2094) (CAT#: CBMAB-L2237-YJ)

Rabbit Anti-LSP1 (Phosphorylated S190) Recombinant Antibody (CAT#: PTM-CBMAB-0945LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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