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Rabbit Anti-LSP1 (Phosphorylated S190) Recombinant Antibody (PTM-CBMAB-0945LY)

This antibody is a recombiant antibody against LSP1. The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all LSP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application
ELISA, WB, IHC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lymphocyte-specific protein 1
Entrez Gene ID
Human4046
Mouse16985
Rat361680
UniProt ID
HumanP33241
MouseP19973
RatQ4QQV6
Function
May play a role in mediating neutrophil activation and chemotaxis.
Biological Process
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-7IEA:Ensembl
ChemotaxisIEA:Ensembl
Signal transductionIEA:InterPro
Cellular Location
Cell membrane
PTM
Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).

Hilchey, S. P., Palshikar, M. G., Mendelson, E. S., Shen, S., Rasam, S., Emo, J. A., ... & Zand, M. S. (2022). Cyclosporine A modulates LSP1 protein levels in Human B cells to attenuate B cell migration at low O2 Levels. Life, 12(8), 1284.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein–Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Le, N. P. K., do Nascimento, A. F., Schneberger, D., Quach, C. C., Zhang, X., Aulakh, G. K., ... & Singh, B. (2022). Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model. Respiratory Research, 23(1), 1-16.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Chen, J., Xiao, Q., Li, X., Liu, R., Long, X., Liu, Z., ... & Li, Y. (2022). The correlation of leukocyte-specific protein 1 (LSP1) rs3817198 (T> C) polymorphism with breast cancer: A meta-analysis. Medicine, 101(45).

Koral, K., Bhushan, B., Stoops, J., Orr, A., Mars, W., & Michalopoulos, G. (2020). Lymphocyte Specific Protein‐1 suppresses TCPOBOP induced hepatocellular proliferation. The FASEB Journal, 34(S1), 1-1.

Cao, J. Y., Guo, Q., Guan, G. F., Zhu, C., Zou, C. Y., Zhang, L. Y., ... & Li, G. Y. (2020). Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma. Aging (Albany NY), 12(2), 1656.

Kwon, R., Hong, B. K., Lee, K. G., Choi, E., Sabbagh, L., Cho, C. S., ... & Kim, W. U. (2020). Regulation of tumor growth by leukocyte-specific protein 1 in T cells. Journal for Immunotherapy of Cancer, 8(2).

Kulkarni, R., Jiang, S., Birrane, G., & Prasad, A. (2020). Lymphocyte‐specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST‐2)‐mediated intracellular trafficking of HIV‐1 in dendritic cells. FEBS letters, 594(12), 1947-1959.

Smeir, M. (2019). Leukocyte specific protein-1 modulates expression and activity of endothelial nitric oxide synthase (Doctoral dissertation, University of Saskatchewan).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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