Mouse Anti-LSP1 Recombinant Antibody (CBYCL-510) (CBMAB-L0411-YC)

Name: Mouse Anti-LSP1 Recombinant Antibody (CBYCL-510)
SKU: CBMAB-L0411-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-510

Application

WB, IHC, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

lymphocyte-specific protein 1

Introduction

LSP1 (Lymphocyte Specific Protein 1) is a protein coding gene and may play a role in mediating neutrophil activation and chemotaxis. Diseases associated with LSP1 include Neutrophil Actin Dysfunction. Among its related pathways are C-type lectin receptor signaling pathway and p38 signaling mediated by MAPKAP kinases. Gene Ontology annotations related to this gene include actin binding and obsolete signal transducer activity.

Entrez Gene ID

4046

UniProt ID

P33241

Alternative Names

WP34; pp52

Function

May play a role in mediating neutrophil activation and chemotaxis.

Biological Process

Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-7IEA:Ensembl
ChemotaxisIEA:Ensembl
Signal transductionIEA:InterPro

Cellular Location

Cell membrane

PTM

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).

Hilchey, S. P., Palshikar, M. G., Mendelson, E. S., Shen, S., Rasam, S., Emo, J. A., ... & Zand, M. S. (2022). Cyclosporine A modulates LSP1 protein levels in Human B cells to attenuate B cell migration at low O2 Levels. Life, 12(8), 1284.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein–Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Le, N. P. K., do Nascimento, A. F., Schneberger, D., Quach, C. C., Zhang, X., Aulakh, G. K., ... & Singh, B. (2022). Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model. Respiratory Research, 23(1), 1-16.

Koral, K., Bhushan, B., Orr, A., Stoops, J., Bowen, W. C., Copeland, M. A., ... & Michalopoulos, G. K. (2022). Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation. The American Journal of Pathology, 192(6), 887-903.

Chen, J., Xiao, Q., Li, X., Liu, R., Long, X., Liu, Z., ... & Li, Y. (2022). The correlation of leukocyte-specific protein 1 (LSP1) rs3817198 (T> C) polymorphism with breast cancer: A meta-analysis. Medicine, 101(45).

Koral, K., Bhushan, B., Stoops, J., Orr, A., Mars, W., & Michalopoulos, G. (2020). Lymphocyte Specific Protein‐1 suppresses TCPOBOP induced hepatocellular proliferation. The FASEB Journal, 34(S1), 1-1.

Cao, J. Y., Guo, Q., Guan, G. F., Zhu, C., Zou, C. Y., Zhang, L. Y., ... & Li, G. Y. (2020). Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma. Aging (Albany NY), 12(2), 1656.

Kwon, R., Hong, B. K., Lee, K. G., Choi, E., Sabbagh, L., Cho, C. S., ... & Kim, W. U. (2020). Regulation of tumor growth by leukocyte-specific protein 1 in T cells. Journal for Immunotherapy of Cancer, 8(2).

Kulkarni, R., Jiang, S., Birrane, G., & Prasad, A. (2020). Lymphocyte‐specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST‐2)‐mediated intracellular trafficking of HIV‐1 in dendritic cells. FEBS letters, 594(12), 1947-1959.

Smeir, M. (2019). Leukocyte specific protein-1 modulates expression and activity of endothelial nitric oxide synthase (Doctoral dissertation, University of Saskatchewan).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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