LSR

LSR probable play a role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.

Full Name

LSR

Function

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).

Biological Process

Epithelial structure maintenanceISS:UniProtKB
Establishment of blood-brain barrierISS:ARUK-UCL
Establishment of skin barrierISS:ARUK-UCL
Liver developmentISS:HGNC
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Protein localization to tricellular tight junctionISS:ARUK-UCL
Tricellular tight junction assemblyISS:ARUK-UCL

Cellular Location

Cell membrane
Cell junction, tight junction
Located at tricellular contacts.

Topology

Extracellular: 1-259
Helical: 260-280
Cytoplasmic: 281-649

PTM

Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.

Anti-LSR antibodies

Mouse Anti-LSR Recombinant Antibody (CBYCL-513) (CBMAB-L0414-YC)

Datasheet

SDS

Target: LSR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-513

Application*: IC, C, P, E, WB

Mouse Anti-LSR Recombinant Antibody (CBYCL-514) (CBMAB-L0415-YC)

Datasheet

SDS

Target: LSR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-514

Application*: E, WB

Rabbit Anti-LSR Recombinant Antibody (CBYCL-515) (CBMAB-L0416-YC)

Datasheet

SDS

Target: LSR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBYCL-515

Application*: WB, IP, P

Mouse Anti-LSR Recombinant Antibody (CBYJL-2095) (CBMAB-L2239-YJ)

Datasheet

SDS

Target: LSR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-2095

Application*: E, IC, IH, WB

Mouse Anti-LSR Recombinant Antibody (A944) (CBMAB-AP4295LY)

Datasheet

SDS

Target: LSR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A944

Application*: ICC, IHC, IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)